668-02-015 ISMRM Abstract

Revisiting an Aspect of GBCA Stability in the Context of Copper Metabolism Disorders through Relaxometry Insights

Primary: Contrast Mechanisms - Contrast Agents

Secondary: Contrast Mechanisms - Relaxometry

668-02-015 · Spectroscopy and Spectroscopic Imaging: Applications · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row I

Keywords: Gadolinium Based Contrast Agents Gadolinium Deposition GBCA Safety Copper Metabolism Disorders GBCA Stability

Accepted

Patrick Werner ^1,2, Matthias Taupitz², Susanne Wagner³, Leif Schröder^4,5,6

¹Translational Molecular Imaging, German Cancer Research Center (DKFZ), Heidelberg, Germany

²Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

³Toxicology Consultant, MSL Management, Marlow, Germany

⁴Devision of Translational Molecular Imaging, German Cancer Research Center (DKFZ), Heidelberg, Germany

⁵Core Center Heidelberg, German Cancer Consortium (DKTK), Heidelberg, Germany

⁶Department of Physics and Astronomy, Ruprecht Karls University Heidelberg, Heidelberg, Germany

Presenting Author: Patrick Werner

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References

1. Semelka RC, Ramalho J, Vakharia A, et al. Gadolinium deposition disease: Initial description of a disease that has been around for a while. Magn Reson Imaging. 2016;34(10):1383-1390. doi:10.1016/j.mri.2016.07.016 [doi]

2. Sherry AD, Caravan P, Lenkinski RE. Primer on gadolinium chemistry. J Magn Reson Imaging. 2009;30(6):1240-1248. doi:10.1002/jmri.21966 [doi]

3. Al-Obaidi, Ruqayah GY, and Bassam MS Al-Musawi. "Spectrum and classification of ATP7B variants with clinical correlation in children with Wilson disease." Saudi Medical Journal 46.2 (2025): 131.

4. Garbuz, Mikhail, et al. "Spectrum of Pathogenic Variants of the ATP7B Gene and Genotype–Phenotype Correlation in Eastern Eurasian Patient Cohorts with Wilson’s Disease." Biomedicines 12.12 (2024): 2833.

5. Ramalho J, Semelka RC, Ramalho M, Nunes RH, AlObaidy M, Castillo M. Gadolinium-Based Contrast Agent Accumulation and Toxicity: An Update. AJNR Am J Neuroradiol. (2016):1192-1198. doi:10.3174/ajnr.A4615 [doi]

6. Werner, Patrick, et al. "An NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator." Scientific reports 11.1 (2021): 21731.

7. Taupitz, Matthias, et al. "Gadolinium‐containing magnetic resonance contrast media: investigation on the possible transchelation of Gd3+ to the glycosaminoglycan heparin." Contrast media & molecular imaging 8.2 (2013): 108-116.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/668-02-015