Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-05-008 ISMRM Abstract

Resorcinarene trimer amine (R3A) – a hyperpolarized xenon-129 dual-contrast molecular imaging agent

Primary: Contrast Mechanisms - Hyperpolarized MR (Gas)
Secondary: Contrast Mechanisms - Multi-Contrast
369-05-008 · Hyperpolarized Gases · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row J
Keywords: Hyperpolarized MRI HyperCEST T2-star Resorcinarene trimer amine Xenon-129
Accepted
Yurii Shepelytskyi1,2, Viktoriia Batarchuk1,2, Mackenzie D Dillon1, Rubiya Mohammed3, Guillem Dayer2,4, Carson L Hasselbrink5, Mitchell Albert2,6
1Chemistry, Lakehead University, Thunder Bay, Canada
2Thunder Bay Regional Health Research Institute, Thunder Bay, Canada
3Chemistry and Materials Science Program, Lakehead University, Thunder Bay, Canada
4Biology, Lakehead University, Thunder Bay, Canada
5Chemistry & Biochemistry, California Polytechnic State University, San Luis Obispo, United States of America
6Lakehead University, Thunder Bay, Canada
Presenting Author: Tao Li

Synopsis

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References

1. Batarchuk, V.; Shepelytskyi, Y.; Grynko, V.; Kovacs, A. H.; Hodgson, A.; Rodriguez, K.; Aldossary, R.; Talwar, T.; Hasselbrink, C.; Ruset, I. C.; Deboef, B.; Albert, M. S. Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges. Int. J. Mol. Sci. 2024, 25 (3), 1939. doi:10.3390/IJMS25031939 [doi]
2. Rowe, S. P.; Pomper, M. G. Molecular Imaging in Oncology: Current Impact and Future Directions. CA. Cancer J. Clin. 2022, 72 (4), 333–352. doi:10.3322/CAAC.21713 [doi]
3. Schroder, L.; Lowery, T. J.; Hilty, C.; Wemmer, D. E.; Pines, A. Molecular Imaging Using a Targeted Magnetic Resonance Hyperpolarized Biosensor. Science (80-. ). 2006, 314 (5798), 446–449. doi:10.1126/science.1131847 [doi]
4. Wang, Y.; Dmochowski, I. J. An Expanded Palette of Xenon-129 NMR Biosensors. Acc. Chem. Res. 2016, 49, 2179–2187. doi:10.1021/acs.accounts.6b00309 [doi]
5. Grynko, V.; Shepelytskyi, Y.; Batarchuk, V.; Aalto, H.; Li, T.; Ruset, I. C.; DeBoef, B.; Albert, M. S.; Grynko, V.; Shepelytskyi, Y.; Batarchuk, V.; Albert, M.; Li, T.; Aalto, H. Cucurbit[6]Uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0T. ChemPhysChem 2023, 24 (23), e202300346. doi:10.1002/cphc.202300346 [doi]
6. Kunth, M.; Schröder, L. Binding Site Exchange Kinetics Revealed through Efficient Spin-Spin Dephasing of Hyperpolarized 129Xe. Chem. Sci. 2021, 12 (1), 158–169. doi:10.1039/d0sc04835f [doi]
7. Zemerov, S. D.; Dmochowski, I. J. Cryptophane-Xenon Complexes For129Xe MRI Applications. RSC Adv. 2021, 11 (13), 7693–7703. doi:10.1039/d0ra10765d [doi]
8. Fernando, P. U. A.; Shepelytskyi, Y.; Cesana, P.; Wade, A.; Grynko, V.; Mendieta, A.; Seveney, L.; Brown, J.; Hane, F.; Albert, M.; DeBoef, B. Decacationic Pillar[5]Arene: A New Scaffold for the Development of 129Xe MRI Imaging Agents. ACS Omega 2020, 5 (43), 27783–27788. doi:10.1021/acsomega.0c02565 [doi]
9. Schnurr, M.; Joseph, R.; Naugolny-Keisar, A.; Kaizerman-Kane, D.; Bogdanoff, N.; Schuenke, P.; Cohen, Y.; Schröder, L. High Exchange Rate Complexes of 129 Xe with Water-Soluble Pillar[5]Arenes for Adjustable Magnetization Transfer MRI. ChemPhysChem 2018, 20 (2), 246–251. doi:10.1002/cphc.201800618 [doi]
10. Shepelytskyi, Y.; Grynko, V.; Batarchuk, V.; Hasselbrink, C. L.; Kovacs, A. H.; Ruset, I. C.; Rodriguez, K.; Al Taradeh, N.; Talwar, T.; DeBoef, B.; Albert, M. S. R3-Noria-Methanesulfonate: A Molecular Cage with Superior Hyperpolarized Xenon-129 MRI Contrast. ACS Sensors 2023, 8 (12), 4707–4715. doi:10.1021/acssensors.3c01791 [doi]
11. Du, K.; Zemerov, S. D.; Hurtado Parra, S.; Kikkawa, J. M.; Dmochowski, I. J. Paramagnetic Organocobalt Capsule Revealing Xenon Host-Guest Chemistry. Inorg. Chem. 2020, 59 (19), 13831–13844. doi:10.1021/acs.inorgchem.9b03634 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-05-008