Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-03-002 ISMRM Abstract

Multiparametric CEST MRI and pH Mapping in Acute and Chronic Ischemic Stroke: Preliminary Clinical Findings

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Contrast Mechanisms - CEST / APT / NOE
369-03-002 · Multiparametric MRI in Stroke · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row J
Keywords: CEST / APT / NOE Clinical application Ischemic Stroke
Accepted
Shihao Zeng1, Shan Huang1,2, Roxanna Kwok Chee Liu3, Zhixuan Ren3, Huabin Zhang1,4, Yuen Kwun Wong3, Ziyan Wang1, Jiawen Wang 1, Ying Zhang1, PEI CAI1, Yi Zhang5, Gary Kui Kai Lau3,6, Jianpan Huang1,6, Kannie W. Y. Chan7,8,9,10,11,12
1Department of Diagnostic Radiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
2Department of Engineering, University of Cambridge, Cambridge, United Kingdom
3Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
4Medical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, He Fei, China
5Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
6Tam Wing Fan Neuroimaging Research Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
7Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China
8Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China
9Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
10State Key Laboratory of Terehertz and Millimeter Waves, City University of Hong Kong, Hong Kong, China
11Tung Biomedical Sciences Centre (TBSC), City University of Hong Kong, Hong Kong, China
12Institute of Digital Medicine, City University of Hong Kong, Hong Kong, China
Presenting Author: Jiawen Wang

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Allen LM, Hasso AN, Handwerker J, Farid H. Sequence-specific MR imaging findings that are useful in dating ischemic stroke. Radiographics 2012;32(5):1285-1297. https://doi.org/10.1148/rg.325115760 [doi]
2. Merino JG, Warach S. Imaging of acute stroke. Nat Rev Neurol 2010;6(10):560-571. https://doi.org/10.1038/nrneurol.2010.129 [doi]
3. Shah S, Luby M, Poole K, Morella T, Keller E, Benson RT, Lynch JK, Nadareishvili Z, Hsia AW. Screening with MRI for accurate and rapid stroke treatment: SMART. Neurology 2015;84(24):2438-2444. https://doi.org/10.1212/WNL.0000000000001678 [doi]
4. Harston GW, Tee YK, Blockley N, Okell TW, Thandeswaran S, Shaya G, Sheerin F, Cellerini M, Payne S, Jezzard P. Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging. Brain 2015;138(1):36-42. https://doi.org/10.1093/brain/awu374 [doi]
5. Leigh R, Knutsson L, Zhou J, van Zijl PC. Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke. J Cereb Blood Flow Metab 2018;38(9):1500-1516. https://doi.org/10.1177/0271678X17700913 [doi]
6. Heo HY, Tee YK, Harston G, Leigh R, Chappell MA. Amide proton transfer imaging in stroke. NMR Biomed 2023;36(6):e4734. https://doi.org/10.1002/nbm.4734 [doi]
7. Tietze A, Blicher J, Mikkelsen IK, Østergaard L, Strother MK, Smith SA, Donahue MJ. Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI. NMR Biomed 2014;27(2):163-174. https://doi.org/10.1002/nbm.3048 [doi]
8. Foo LS, Harston G, Mehndiratta A, Yap W-S, Hum YC, Lai KW, Mukari SAM, Zaki FM, Tee YK. Clinical translation of amide proton transfer (APT) MRI for ischemic stroke: a systematic review (2003–2020). Quantitative Imaging in Medicine and Surgery 2021;11(8):3797. doi: 10.21037/qims-20-1339 [doi]
9. Li H, Zu Z, Zaiss M, Khan IS, Singer RJ, Gochberg DF, Bachert P, Gore JC, Xu J. Imaging of amide proton transfer and nuclear Overhauser enhancement in ischemic stroke with corrections for competing effects. NMR Biomed 2015;28(2):200-209. https://doi.org/10.1002/nbm.3243 [doi]
10. Msayib Y, Harston GW, Ray KJ, Larkin JR, Sutherland BA, Sheerin F, Blockley NP, Okell TW, Jezzard P, Baldwin A. Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke. Magn Reson Med 2022;88(1):341-356. https://doi.org/10.1002/mrm.29187 [doi]
11. Tourdias T, Dousset V, Sibon I, Pele E, Menegon P, Asselineau J, Pachai C, Rouanet F, Robinson P, Chene G. Magnetization transfer imaging shows tissue abnormalities in the reversible penumbra. Stroke 2007;38(12):3165-3171. https://doi.org/10.1161/STROKEAHA.107.483925 [doi]
12. Sibon I, Tourdias T, Felix S, Asselineau J, Bracoud L, Vivot A, Rouanet F, Renou P, Orgogozo J, Dousset V. Magnetisation transfer parameters and stroke outcome. Journal of Clinical Neuroscience 2015;22(6):1012-1017. https://doi.org/10.1016/j.jocn.2014.11.035 [doi]
13. McVicar N, Li AX, Goncalves DF, Bellyou M, Meakin SO, Prado MA, Bartha R. Quantitative tissue pH measurement during cerebral ischemia using amine and amide concentration-independent detection (AACID) with MRI. J Cereb Blood Flow Metab 2014;34(4):690-698. https://doi.org/10.1038/jcbfm.2014.12 [doi]
14. Huang J, Chan MYM, Zhang Y, Lau GKK, Chan KWY. Assessment of molecular and pH weighted signal changes in chronic ischemic stroke using CEST MRI at 3T. 2025 10/05-15/05; Honolulu, Hawaiʻi, USA.
15. Kwah LK, Diong J. National institutes of health stroke scale (NIHSS). Journal of physiotherapy 2014;60(1):61. https://doi.org/10.1016/j.jphys.2013.12.012 [doi]
16. Adams Jr HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh 3rd E. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. stroke 1993;24(1):35-41. https://doi.org/10.1161/01.STR.24.1.35 [doi]
17. Ashburner J, Barnes G, Chen C-C, Daunizeau J, Flandin G, Friston K, Kiebel S, Kilner J, Litvak V, Moran R. SPM12 manual. Wellcome Trust Centre for Neuroimaging, London, UK 2014;2464(4):53.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-03-002