Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
569-05-014 ISMRM Abstract

A novel MRS fingerprinting approach to estimate concentrations and relaxation times of metabolites, macromolecules, and water

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Acquisition & Reconstruction - Signal Modeling
569-05-014 · Spectroscopy and Spectroscopic Imaging: Methods · Wednesday, 13 May, 4:00 PM–4:55 PM · Digital Posters Row J
Keywords: MR Fingerprinting MRS Relaxation times Magnetic Resonance Spectroscopy Linear-combination modeling
Accepted
Helge J Zöllner 1, Zahra Shams1, Julia Stabinska2, Kimberly L Chan3, Assaf Tal4, Georg Oeltzschner1, Richard AE Edden1, Peter B Barker1,2
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States of America
3University of Texas Southwestern Medical Center, Dallas, United States of America
4Department of Bio-Medical Engineering, Tel Aviv University, Tel Aviv, Israel
Presenting Author: Helge J Zöllner

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References

1. Öz G, Alger JR, Barker PB, et al. Clinical Proton MR Spectroscopy in Central Nervous System Disorders. Radiology. 2014;270(3):658-679. doi:10.1148/radiol.13130531 [doi]
2. Near J, Harris AD, Juchem C, et al. Preprocessing, analysis and quantification in single-voxel magnetic resonance spectroscopy: experts’ consensus recommendations. NMR Biomed. 2020;34:e4257. doi:10.1002/nbm.4257 [doi]
3. Kulpanovich A, Tal A. The application of magnetic resonance fingerprinting to single voxel proton spectroscopy. NMR Biomed. 2018;31(11):e4001. doi:10.1002/nbm.4001 [doi]
4. Kulpanovich A, Tal A. What is the optimal schedule for multiparametric MRS? A magnetic resonance fingerprinting perspective. NMR Biomed. 2021;34(5):e4196. doi:10.1002/nbm.4196 [doi]
5. Deelchand DK, Berrington A, Noeske R, et al. Across-vendor standardization of semi-LASER for single-voxel MRS at 3T. NMR Biomed. 2021;34(5):e4218. doi:10.1002/nbm.4218 [doi]
6. Chan KL, Ouwerkerk R, Barker PB. Water suppression in the human brain with hypergeometric RF pulses for single-voxel and multi-voxel MR spectroscopy. Magn Reson Med. 2018;80(4):1298-1306. doi:10.1002/mrm.27133 [doi]
7. Mlynárik V, Gruber S, Moser E. Proton T1 and T2 relaxation times of human brain metabolites at 3 Tesla. NMR Biomed. 2001;14(5):325-331. doi:10.1002/nbm.713 [doi]
8. Wyss PO, Bianchini C, Scheidegger M, et al. In vivo estimation of transverse relaxation time constant (T2) of 17 human brain metabolites at 3T. Magn Reson Med. 2018;80(2):452-461. doi:10.1002/mrm.27067 [doi]
9. Wansapura JP, Holland SK, Dunn RS, Ball WS. NMR relaxation times in the human brain at 3.0 Tesla. J Magn Reson Imaging. 1999;9(4):531-538. doi:10.1002/(SICI)1522-2586(199904)9:4<531::AID-JMRI4>3.0.CO;2-L [doi]
10. Puts NAJ, Barker PB, Edden RAE. Measuring the longitudinal relaxation time of GABA in vivo at 3T. J Magn Reson Imaging JMRI. 2013;37(4):999-1003. doi:10.1002/jmri.23817 [doi]
11. Landheer K, Gajdošík M, Treacy M, Juchem C. Concentration and effective T2 relaxation times of macromolecules at 3T. Magn Reson Med. 2020;84(5):2327-2337. doi:10.1002/mrm.28282 [doi]
12. Oeltzschner G, Zöllner HJ, Hui SCN, et al. Osprey: Open-source processing, reconstruction & estimation of magnetic resonance spectroscopy data. J Neurosci Methods. 2020;343:108827. doi:10.1016/j.jneumeth.2020.108827 [doi]
13. Zöllner HJ, Davies-Jenkins C, Simicic D, Tal A, Sulam J, Oeltzschner G. Simultaneous multi-transient linear-combination modeling of MRS data improves uncertainty estimation. Magn Reson Med. 2024;92(3):916-925. doi:10.1002/mrm.30110 [doi]
14. Gasparovic C, Song T, Devier D, et al. Use of tissue water as a concentration reference for proton spectroscopic imaging. Magn Reson Med. 2006;55(6):1219-1226. doi:10.1002/mrm.20901 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/569-05-014