Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
467-02-010 ISMRM Abstract

High resolution lipid composition map in high grade breast tumour using chemical shift-encoded imaging on 9.4T preclinical MR

Primary: Acquisition & Reconstruction - Quantitative Imaging: chest, abdomen, and pelvis
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
467-02-010 · Quantitative Pelvic, Thorax, and Abdomen · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row H
Keywords: Breast cancer Ultra-high resolution Chemical Shift-Encoded MRI Lipid composition Mechanistic actions
Accepted
Sai Man Cheung 1, Kwok-Shing Chan2,3, Kangwa A Nkonde1, Yazan Ayoub4, Nicholas Senn4, Bernard Siow5, Jiabao He1
1Newcastle Magnetic Resonance Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
3Harvard Medical School, Boston, United States of America
4Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom
5In Vivo Imaging, The Francis Crick Institute, London, United Kingdom
Presenting Author: Sai Man Cheung

Synopsis

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References

1. Neiman KM, Kenny HA, Penicka CV, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011;17(11):1498-1503. doi: 10.1038/nm.2492. [doi]
2. Wang YY, Attané C, Milhas D, et al. Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells. JCI Insight. 2017;2(4):1-20. doi: 10.1172/jci.insight.87489. [doi]
3. Bydder M, Girard O, Hamilton G. Mapping the double bonds in triglycerides. Magn Reson Imaging. 2011;29(8):1041-1046. doi: 10.1016/j.mri.2011.07.004. [doi]
4. Peterson P, Månsson S. Simultaneous quantification of fat content and fatty acid composition using MR imaging. Magn Reson Med. 2013;69(3):688-697. doi: 10.1002/mrm.24297. [doi]
5. Chan KS, Cheung SM, Senn N, et al. Peri-tumoural spatial distribution of lipid composition and tubule formation in breast cancer. BMC Cancer. 2022;22(1):285. doi: 10.1186/s12885-022-09362-1. [doi]
6. Cheung SM, Chan KS, Zhou WS, et al. Spatial heterogeneity of peri-tumoural lipid composition in postmenopausal patients with oestrogen receptor positive breast cancer. Sci Rep. 2024;14(1):4699. doi: 10.1038/s41598-024-55458-y. [doi]
7. He Q, Shkarin P, Hooley RJ, et al. In vivo MR spectroscopic imaging of polyunsaturated fatty acids (PUFA) in healthy and cancerous breast tissues by selective multiple-quantum coherence transfer (Sel-MQC): A preliminary study. Magn Reson Med. 2007;58(6):1079-1085. doi: 10.1002/mrm.21335. [doi]
8. Azad M, Turgeon C, Demark-Wahnefried W. Current evidence linking polyunsaturated fatty acids with cancer risk and progression. Front Oncol. 2013;3(1):224. doi: 10.3389/fonc.2013.00224. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/467-02-010