663-01-006 ISMRM Abstract

Quantitative Evaluation of Mouse Liver Perfusion Using Proton MRI with Deuterium Oxide–Containing Perfusate

Primary: Preclinical Animal & in vitro MR

Secondary: Analysis Methods - Visualization

663-01-006 · Diffusion MRI, Iron Quantification, and Steatosis in Human and Preclinical Studies · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row D

Keywords: Preclinical Transplantation Deuterium Liver Perfusion

Accepted

Hitoshi Kubo ¹, Haru Wakutsu¹, Urara Hirano², Hayato Aoyama¹, Kou Kumagai², Takashi Iwanaga¹

¹Department of Radiological Sciences, School of Health Science, Fukushima Medical University, Fukushima, Japan

²School of Graduate Education, Fukushima Medical University, Fukushima, Japan

Presenting Author: Hitoshi Kubo

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References

1. Guibert EE, Petrenko AY, Balaban CL, et al. Organ Preservation: Current Concepts and New Strategies for the Next Decade. Transfus Med Hemother. 2011;38(2):125–142. doi: 10.1159/000327033, PMID: 21566713 [doi] [pmid]

2. Desai CS Gerber DA. Concise review of machine perfusion in liver transplantation. World J Hepatol. 2020;12(1):6–9. doi:10.4254/wjh.v12.i1.6, PMID: 31984116 [doi] [pmid]

3. Schoeller DA, Santen EV, Peterson DW, et al. Total body water measurement in humans with 18O and 2H labeled water. Am J Clin Nutr. 1980;33(12):2686-93. doi:10.1093/ajcn/33.12.2686., PMID: 6776801 [doi] [pmid]

4. Lichtenbelt WM, Westerterp KR, Wouters L. Deuterium dilution as a method for determining total body water: effect of test protocol and sampling time. British Journal of Nutrition. 1994;72:491-497.

5. Chen L, Liu J, Chu C, et al. Deuterium oxide as a contrast medium for real-time MRI-guided endovascular neurointervention. Theranostics. 2021;11(13):6240–6250. doi:10.7150/thno.55953, PMID: 33995656 [doi] [pmid]

6. SOP 7.15 - Whole Body Perfusion for Small Rodents (Mice), Queen’s University, April 11, 2012. https://www.queensu.ca/animals-in-science/policies-procedures/sop/mice/7-15. Accessed October 24, 2025.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-01-006