569-06-002 ISMRM Abstract

Sensitivity of literature T1 mapping methods to the underlying magnetization transfer parameters

Primary: Contrast Mechanisms - Relaxometry

Secondary: Contrast Mechanisms - Magnetization Transfer

569-06-002 · Magnetization Transfer and Relaxometry · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row J

Keywords: Magnetization transfer Relaxometry Relaxation times Quantitative MRI T1

Accepted

Jakob Assländer ^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, United States of America

²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, United States of America

Presenting Author: Jakob Assländer

Synopsis

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References

1. Nikola Stikov et al. “On the accuracy of T1 mapping: Searching for common ground”. In: Magnetic Resonance in Medicine 73.2 (2015), pp. 514–522. ISSN: 1522-2594. DOI: 10.1002/mrm.25135. [doi]

2. Xiawei Ou and Daniel Frank Gochberg. “MT eﬀects and T1 quantiﬁcation in singleslice spoiled gradient echo imaging”. In: Magnetic Resonance in Medicine 59.4 (2008), pp. 835–845. ISSN: 0740-3194. DOI: 10.1002/mrm.21550. [doi]

3. Jorge Zavala Bojorquez et al. “What are normal relaxation times of tissues at 3 T?” In: Magnetic Resonance Imaging 35 (2017), pp. 69–80. ISSN: 0730-725X. DOI: 10.1016/j.mri.2016.08.021. [doi]

4. Rui Pedro A.G. Teixeira, Shaihan J. Malik, and Joseph V. Hajnal. “Fast quantitative MRI using controlled saturation magnetization transfer”. In: Magnetic Resonance in Medicine 81.2 (2019), pp. 907–920. ISSN: 0740-3194. DOI: 10.1002/mrm.27442. [doi]

5. Steven D. Wolﬀ and Robert S. Balaban. “Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo”. In: Magnetic Resonance in Medicine 10.1 (1989), pp. 135–144. ISSN: 1522-2594. DOI: 10.1002/mrm.1910100113. [doi]

6. R. Mark Henkelman et al. “Quantitative interpretation of magnetization transfer”. In: Magnetic Resonance in Medicine 29.6 (1993), pp. 759–766. ISSN: 1522-2594. DOI: 10.1002/mrm.1910290607. [doi]

7. Jakob Assländer and Sebastian Flassbeck. “Magnetization transfer explains most of the T1 variability in the MRI literature”. In: Magnetic Resonance in Medicine 94.1 (2025), pp. 293–301. ISSN: 0740-3194. DOI: 10.1002/mrm.30451. [doi]

8. Greg J. Stanisz et al. “T1, T2 relaxation and magnetization transfer in tissue at 3T”. In: Magnetic Resonance in Medicine 54.3 (2005), pp. 507–512. ISSN: 1522-2594. DOI: 10.1002/mrm.20605. [doi]

9. C. Preibisch and R. Deichmann. “Inﬂuence of RF spoiling on the stability and accuracy of T1 mapping based on spoiled FLASH with varying ﬂip angles”. In: Magnetic Resonance in Medicine 61.1 (2009), pp. 125–135. ISSN: 1522-2594. DOI: 10.1002/mrm.21776. [doi]

10. Wanyong Shin, Hong Gu, and Yihong Yang. “Fast highresolution T1 mapping using inversion-recovery look-locker echoplanar imaging at steady state: Optimization for accuracy and reliability”. In: Magnetic Resonance in Medicine 61.4 (2009), pp. 899–906. ISSN: 0740-3194. DOI: 10.1002/mrm.21836. [doi]

11. Hanzhang Lu et al. “Routine clinical brain MRI sequences for use at 3.0 Tesla”. In: Journal of Magnetic Resonance Imaging 22.1 (2005), pp. 13–22. ISSN: 1053-1807. DOI: 10.1002/jmri.20356. [doi]

12. Luke A. Reynolds et al. “Nonaqueous magnetization following adiabatic and selective pulses in brain: T1 and crossrelaxation dynamics”. In: NMR in Biomedicine 36.8 (2023), e4936. ISSN: 0952-3480. DOI: 10.1002/nbm.4936. [doi]

13. P. J. Wright et al. “Water proton T1 measurements in brain tissue at 7, 3, and 1.5T using IR-EPI, IR-TSE, and MPRAGE: results and optimization”. In: Magnetic Resonance Materials in Physics, Biology and Medicine 21.1-2 (2008), p. 121. ISSN: 0968-5243. DOI: 10.1007/s10334-008-0104-8. [doi]

14. HaiLing Margaret Cheng and Graham A Wright. “Rapid highresolution T1 mapping by variable ﬂip angles: Accurate and precise measurements in the presence of radiofrequency ﬁeld inhomogeneity”. In: Magnetic Resonance in Medicine 55.3 (2006), pp. 566–574. ISSN: 1522-2594. DOI: 10.1002/mrm.20791. [doi]

15. C. Preibisch and R. Deichmann. “T1 mapping using spoiled FLASHEPI hybrid sequences and varying ﬂip angles”. In: Magnetic Resonance in Medicine 62.1 (2009), pp. 240–246. ISSN: 0740-3194. DOI: 10.1002/mrm.21969. [doi]

16. Soﬁa Chavez and Greg J. Stanisz. “A novel method for simultaneous 3D B1 and T1 mapping: the method of slopes (MoS)”. In: NMR in Biomedicine 25.9 (2012), pp. 1043–1055. ISSN: 0952-3480. DOI: 10.1002/nbm.2769. [doi]

17. José P. Marques et al. “MP2RAGE, a self bias-ﬁeld corrected sequence for improved segmentation and T1-mapping at high ﬁeld”. In: NeuroImage 49.2 (2010), pp. 1271–1281. ISSN: 1053-8119. DOI: 10.1016/j.neuroimage.2009.10.002. [doi]

18. Jakob Assländer et al. “Generalized Bloch model: A theory for pulsed magnetization transfer”. In: Magnetic Resonance in Medicine 87.4 (2022), pp. 2003–2017. ISSN: 0740-3194. DOI: 10.1002/mrm.29071. [doi]

19. Gunther Helms and Gisela E Hagberg. “In vivo quantiﬁcation of the bound pool T1 in human white matter using the binary spinbath model of progressive magnetization transfer saturation”. In: Physics in Medicine and Biology 54.23 (2009), N529–N540. ISSN: 0031-9155. DOI: 10.1088/0031-9155/54/23/n01. [doi]

20. Peter van Gelderen, Xu Jiang, and Jeﬀ H. Duyn. “Eﬀects of magnetization transfer on T1 contrast in human brain white matter”. In: NeuroImage 128 (2016), pp. 85–95. ISSN: 1053-8119. DOI: 10.1016/j.neuroimage.2015.12.032. [doi]

21. Jakob Assländer et al. “Unconstrained quantitative magnetization transfer imaging: Disentangling T1 of the free and semi-solid spin pools”. In: Imaging Neuroscience 2 (2024), imag–2-00177. DOI: 10.1162/imag_a_00177. [doi]

22. Shinichi Nakagawa and Holger Schielzeth. “A general and simple method for obtaining R2 from generalized linear mixedeﬀects models”. In: Methods in Ecology and Evolution 4.2 (2013), pp. 133–142. ISSN: 2041-210X. DOI: 10.1111/j.2041-210x.2012.00261.x. [doi]

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