Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-02-010 ISMRM Abstract

Correlation Analysis Between Apathy Symptoms and Multi-Parameter Glymphatic Indicators in Parkinson's Disease

Primary: Neuro - Parkinson's Disease
Secondary: Neuro - White Matter
369-02-010 · Imaging Parkinson’s Disease: Multimodal Biomarkers of Progression and Phenotype · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row J
Keywords: Parkinson's Disease Perivascular spaces Glymphatic system Choroid plexus volume DTI-ALPS index
Accepted
Hao Li 1, Xuelian Zhao2,3, Zhuo Wang3, Jun Wang2, Kai AI4, Yao G Liu2, Jing Zhang1,2
1Department of Magnetic Resonance, Lanzhou, China
2The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China
3Department of Magnetic Resonance, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China
4Department of Clinical and Technical Support, Philips Healthcare (Xi'an), Xi'an, China
Presenting Author: Hao Li

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Iliff J J, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β [J]. Sci Transl Med, 2012, 4(147): 147ra11. DOI: 10.1126/scitranslmed.3003748. [doi]
2. Lin F, Yang B, Chen Y, et al. Enlarged perivascular spaces are linked to freezing of gait in Parkinson's disease [J]. Front Neurol, 2022, 13: 985294. DOI: 10.3389/fneur.2022.985294. [doi]
3. Wood K H, Nenert R, Miften A M, et al. Diffusion Tensor Imaging-Along the Perivascular-Space Index Is Associated with Disease Progression in Parkinson's Disease [J]. Mov Disord, 2024, 39(9): 1504-13. DOI: 10.1002/mds.29908. [doi]
4. De Deus Vieira G, Antônio F F, Damasceno A. Enlargement of the choroid plexus in pediatric multiple sclerosis [J]. Neuroradiology, 2024, 66(7): 1199-202. DOI: 10.1007/s00234-024-03366-3. [doi]
5. Zhao J, Jia H, Ma P, et al. Multidimensional mechanisms of anxiety and depression in Parkinson's disease: Integrating neuroimaging, neurocircuits, and molecular pathways [J]. Pharmacol Res, 2025, 215: 107717. DOI: 10.1016/j.phrs.2025.107717. [doi]
6. Jiang-Xie L F, Drieu A, Kipnis J. Waste clearance shapes aging brain health [J]. Neuron, 2025, 113(1): 71-81. DOI: 10.1016/j.neuron.2024.09.017. [doi]
7. Schonhoff A M, Figge D A, Williams G P, et al. Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease [J]. Nat Commun, 2023, 14(1): 3754. DOI: 10.1038/s41467-023-39060-w. [doi]
8. Wu W, Zhao Y, Cheng X, et al. Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer's disease [J]. Nat Commun, 2025, 16(1): 63. DOI: 10.1038/s41467-024-55678-w. [doi]
9. Dai X, Zhang Y, Fu C, et al. Investigating glymphatic function and bed nucleus of the stria terminalis-based functional connectivity in Parkinson's disease with and without depression [J]. NPJ Parkinsons Dis, 2025, 11(1): 129. DOI: 10.1038/s41531-025-00985-2. [doi]
10. Yang C, Tian S, Du W, et al. Glymphatic function assessment with diffusion tensor imaging along the perivascular space in patients with major depressive disorder and its relation to cerebral white-matter alteration [J]. Quant Imaging Med Surg, 2024, 14(9): 6397-412. DOI: 10.21037/qims-24-510. [doi]
11. Lucas-Jiménez O, Ojeda N, Peña J, et al. Apathy and brain alterations in Parkinson's disease: a multimodal imaging study [J]. Ann Clin Transl Neurol, 2018, 5(7): 803-14. DOI: 10.1002/acn3.578. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-02-010