668-02-003 ISMRM Abstract

Impaired Neurometabolism in Severe Amyotrophic Lateral Sclerosis Condition: A 1H-[13C]-NMR Analysis in SOD1G93A Mice

Primary: Neuro - Spinal Cord

Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods

668-02-003 · Spectroscopy and Spectroscopic Imaging: Applications · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row I

Keywords: Spinal Cord Glucose metabolism Motor function 1H-13C-NMR Acetate Metabolism

Accepted

Anant B Patel ¹, Sohini Ghosh¹

¹NMR MICROIMAGING AND SPECTROSCOPY, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

Presenting Author: Anant B Patel

Synopsis

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References

1. Wood LK, Langford SJ. Motor neuron disease: a chemical perspective. J Med Chem. 2014;14;57(15):6316-31.

2. Hyder, F, Patel, AB., Gjedde, A, Rothman, DL, Behar KL, & Shulman RG. Neuronal–Glial Glucose Oxidation and Glutamatergic–GABAergic Function. Journal of Cerebral Blood Flow & Metabolism. 2006;26(7): 865–877.

3. Bagga, P, Chugani, A. N, Varadarajan, K. S, & Patel, A. B. In vivo NMR studies of regional cerebral energetics in MPTP model of Parkinson’s disease: Recovery of cerebral metabolism with acute levodopa treatment. Journal of Neurochemistry. 2013;127(3):365– 377

4. Luh LM, Das I, & Bertolotti A, qMotor, a set of rules for sensitive, robust and quantitative measurement of motor performance in mice. Nature Protocal. 2017; Vol. 12 No. 7.1451.

5. Tiwari V, Ambadipudi S, Patel AB. Glutamatergic and GABAergic TCA cycle and neurotransmitter cycling fluxes in different regions of mouse brain. J Cereb Blood Flow Metab. 2013;33(10):1523-31.

6. Patel AB, Rothman DL, Cline GW, Behar KL. Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Res. 2001;23;919(2):207-20.

7. Patel AB, De Graaf RA, Mason, GF, et al. Glutamatergic Neurotransmission and Neuronal Glucose Oxidation are Coupled during Intense Neuronal Activation. Journal of Cerebral Blood Flow & Metabolism. 2004;24(9), 972–985.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/668-02-003