Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
562-05-007 ISMRM Abstract

White Matter Development Following Maternal Iron Supplementation: A Diffusion MRI Study of Intravenous versus Oral Iron

Accepted
Douglas C Dean 1, Virupaxi Hattiholi2,3, Mahesh Kamate2,4, Moriah E Thomason5,6, Kiran S Talekar7, Anmol Patted8, Simal Thind8, Jesse Bradford-Rogers8, Danielle M DeSantis8, Umesh Charantimath9, Manjunath Somannavar10, S Yogeshkumar9, Rebecca Hartman11, Benjamin Leiby11, Roopa Bellad12, Zubair Aghai13,14, Michael Georgieff15,16,17,18, Shivaprasad Goudar19, Mrutyunjaya Bellad20, Richard Derman8
1Department of Medical Physics, University of Wisconsin - Madison, Madison, United States of America
2KAHER's J N Medical College, Belgaum, India
3Department of Radiology, KAHER's J N Medical College, Belgaum, India
4Department of Pediatric Neurology, KAHER's J N Medical College, Belgaum, India
5New York University Langone Health, New York, United States of America
6Department of Population Health, New York University Langone Health, New York, United States of America
7Radiology, Thomas Jefferson University, Philadelphia, United States of America
8Department of Global Affairs, Thomas Jefferson University, Philadelphia, United States of America
9Department of Community Medicine, KAHER's J N Medical College, Belgaum, India
10Department of Biochemistry, KAHER's J N Medical College, Belgaum, India
11Department of Biostatistics and Bioinformatics, Thomas Jefferson University, Philadelphia, United States of America
12Department of Paediatrics, KAHER's J N Medical College, Belgaum, India
13Department of Pediatrics, Thomas Jefferson University, Philadelphia, United States of America
14Thomas Jefferson University, Philadelphia, United States of America
15Department of Pediatrics, University of Minnesota, Minneapolis, United States of America
16Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, United States of America
17Institute of Child Development, University of Minnesota, Minneapolis, United States of America
18Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, United States of America
19Department of Physiology, KAHER's J N Medical College, Belgaum, India
20Department of Obstetrics & Gynecology, KAHER's J N Medical College, Belgaum, India
Presenting Author: Douglas C Dean

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References

1. Georgieff, M. K. The role of iron in neurodevelopment: fetal iron deficiency and the developing hippocampus. Biochem Soc Trans 36, 1267–1271 (2008). https://doi.org/10.1042/BST0361267 [doi]
2. Dubois, J. et al. The early development of brain white matter: a review of imaging studies in fetuses, newborns and infants. Neuroscience 276, 48–71 (2014). https://doi.org/10.1016/j.neuroscience.2013.12.044 [doi]
3. Alexander, A. L. et al. Characterization of cerebral white matter properties using quantitative magnetic resonance imaging stains. Brain Connect 1, 423–446 (2011). https://doi.org/10.1089/brain.2011.0071 [doi]
4. DiPiero, M., Rodrigues, P. G., Gromala, A. & Dean, D. C., 3rd. Applications of advanced diffusion MRI in early brain development: a comprehensive review. Brain Struct Funct 228, 367–392 (2023). https://doi.org/10.1007/s00429-022-02605-8 [doi]
5. Derman, R. J. et al. RAPIDIRON: Reducing Anaemia in Pregnancy in India-a 3-arm, randomized-controlled trial comparing the effectiveness of oral iron with single-dose intravenous iron in the treatment of iron deficiency anaemia in pregnant women and reducing low birth weight deliveries. Trials 22, 649 (2021). https://doi.org/10.1186/s13063-021-05549-2 [doi]
6. Derman, R. J. et al. RAPIDIRON Trial follow-up study - the RAPIDIRON-KIDS Study: protocol of a prospective observational follow-up study. Trials 24, 818 (2023). https://doi.org/10.1186/s13063-023-07740-z [doi]
7. Dean, D. C., 3rd et al. Pediatric neuroimaging using magnetic resonance imaging during non-sedated sleep. Pediatr Radiol 44, 64–72 (2014). https://doi.org/10.1007/s00247-013-2752-8 [doi]
8. Raschle, N. M. et al. Making MR imaging child's play - pediatric neuroimaging protocol, guidelines and procedure. J Vis Exp, e1309 (2009). https://doi.org/10.3791/1309 [doi]
9. Raschle, N. et al. Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines. Ann N Y Acad Sci 1252, 43–50 (2012). https://doi.org/10.1111/j.1749-6632.2012.06457.x [doi]
10. Spann, M. N. et al. The Art, Science, and Secrets of Scanning Young Children. Biol Psychiatry 93, 858–860 (2023). https://doi.org/10.1016/j.biopsych.2022.09.025 [doi]
11. Andersson, J. L. R. & Sotiropoulos, S. N. An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Neuroimage 125, 1063–1078 (2016). https://doi.org/10.1016/j.neuroimage.2015.10.019 [doi]
12. Jenkinson, M., Beckmann, C. F., Behrens, T. E., Woolrich, M. W. & Smith, S. M. Fsl. Neuroimage 62, 782–790 (2012). https://doi.org/10.1016/j.neuroimage.2011.09.015 [doi]
13. Tournier, J. D. et al. MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. Neuroimage 202, 116137 (2019). https://doi.org/10.1016/j.neuroimage.2019.116137 [doi]

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