Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-06-004 ISMRM Abstract

Longitudinally monitoring non-enzymatic crosslinking of collagen in bovine tendon via UTE quantitative MT (UTE-qMT) imaging

Primary: Musculoskeletal - Tendon/Ligament
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
566-06-004 · Quantitative Outcome Measures in MSK MRI · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row G
Keywords: Diabetes Advanced glycation endproduct Collagen crosslink Diabetic tendinopathy
Accepted
Soo Hyun Shin 1, Qingbo Tang1,2, Saeed Jerban1, Yajun Ma1, Eric Y Chang1,2, Jiang Du1,2
1University of California, Berkeley, United States of America
2Radiology Service, VA San Diego Healthcare System, La Jolla, California, San Diego, United States of America
Presenting Author: Soo Hyun Shin

Synopsis

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References

1. Snedeker et al., The role of collagen crosslinks in ageing and diabetes – the good, the bad, and the ugly. Muscles Ligaments Tendons J. 2014;4:303-308.
2. Lee et al., Advanced glycation end-product cross-linking inhibits biomechanical plasticity and characteristic failure morphology of native tendon. J Appl Physiol. 2019;126:832-841.
3. Chang et al., UTE imaging in the musculoskeletal system.JMRI, 2015;41:870-883.
4. Shin et al., Ultrashort echo time magnetization transfer (UTE-MT) MRI detects non-enzymatic crosslinking of collagen in ex vivo rat bones. Proc. ISMRM. 2025;33:0160.
5. Snow et al., Effect of in vitro ribosylation on the dynamic fracture behavior of mature bovine cortical bone. J Mech Behav Biomed Mater. 2023;148:106171.
6. Ma Y, Chang EY, Carl M, Du J. Quantitative magnetization transfer ultrashort echo time imaging using a time-efficient 3D multispoke Cones sequence. Magn Reson Med. 2018;79(2):692-700.
7. Brookes et al., Accuracy of T1 measurement in dynamic contrast-enhanced breast MRI using two- and three-dimensional variable flip angle fast low-angle shot. JMRI. 1999;9:163-171.
8. Jerban et al., Water proton density in human cortical bone obtained from ultrashort echo time (UTE) MRI predicts bone microstructural properties. Magn Reson Imag. 2020;67:85-89.
9. Fishbein KW, Gluzband YA, Kaku M, et al. Effects of formalin fixation and collagen cross-linking on T2 and magnetization transfer in bovine nasal cartilage. Magn Reson Med. 2007;57(6):1000-1011.
10. Ho LC, Sigal IA, Jan NJ, et al. Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation. Sci Rep. 2016;6(1):32080.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/566-06-004