Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
669-01-002 ISMRM Abstract

Quasi-steady-state CEST for rapid and quantitative lesion detection in multiple sclerosis at 3 T

Primary: Contrast Mechanisms - CEST / APT / NOE
Secondary: Neuro - Multiple Sclerosis
669-01-002 · Neuroinflammation: Metabolites, Function, and AI · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row J
Keywords: Multiple Sclerosis CEST-MRI post-processing Quasi-steady-state (QUASS)
Accepted
Huabin Zhang1,2, Ziyan Wang 1, Shihao Zeng1, Jiawen Wang1, PEI CAI1, Ka Fung Henry Mak1, Koon H Chan3, BenSheng Qiu2, Jianpan Huang1,4
1Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
2Medical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China(USTC), Hefei, China
3Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
4Tam Wing Fan Neuroimaging Research Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Presenting Author: Ziyan Wang

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Sospedra M,Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005;23(1):683-747. https://doi.org/10.1146/annurev.immunol.23.021704.115707. [doi]
2. Dobson R,Giovannoni G. Multiple sclerosis–a review. European journal of neurology 2019;26(1):27-40. https://doi.org/10.1111/ene.13819. [doi]
3. Filippi M, Brück W, Chard D, Fazekas F, Geurts JJ, Enzinger C, Hametner S, Kuhlmann T, Preziosa P,Rovira À. Association between pathological and MRI findings in multiple sclerosis. The Lancet Neurology 2019;18(2):198-210. https://doi.org/10.1016/S1474-4422(18)30451-4. [doi]
4. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M,Freedman MS. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. The Lancet Neurology 2018;17(2):162-173. https://doi.org/10.1016/S1474-4422(17)30470-2. [doi]
5. Fernando K, Tozer D, Miszkiel K, Gordon R, Swanton J, Dalton C, Barker G, Plant G, Thompson A,Miller D. Magnetization transfer histograms in clinically isolated syndromes suggestive of multiple sclerosis. Brain 2005;128(12):2911-2925. https://doi.org/10.1093/brain/awh654. [doi]
6. Huang J, Han X, Chen L, Xu X, Xu J,Chan KW. Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3 T. Magnetic resonance in medicine 2021;85(1):254-267. https://doi.org/10.1002/mrm.28433. [doi]
7. Chen Z, Huang J, Lai JH, Tse KH, Xu J,Chan KW. Chemical exchange saturation transfer MRI detects myelin changes in cuprizone mouse model at 3T. NMR in Biomedicine 2023;36(9):e4937. https://doi.org/10.1002/nbm.4937. [doi]
8. Zaiss M,Bachert P. Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods. Physics in Medicine and Biology 2013;58(22):R221. https://doi.org/10.1088/0031-9155/58/22/R221. [doi]
9. Wu Y, Liu Z, Yang Q, Zou L, Zhang F, Qian L, Liu X, Zheng H, Luo D,Sun PZ. Fast and equilibrium CEST imaging of brain tumor patients at 3T. NeuroImage: Clinical 2021;33:102890. https://doi.org/10.1016/j.nicl.2021.102890. [doi]
10. Ying Y, Wang D, Zhao Y, Quan K, Li X, Xie Y, Mei N, Chen J, Ruan Z,Xu R. The Application of Quasi‐Steady‐State Chemical Exchange Saturation Transfer Imaging in the Visualization of Glioma Infiltration and the Optimal Extent of Resection Establishment. Journal of Magnetic Resonance Imaging 2025. https://doi.org/10.1002/jmri.29786. [doi]
11. Jiang W, Zhou IY, Wen L, Zhou X,Sun PZ. A theoretical analysis of chemical exchange saturation transfer echo planar imaging (CEST‐EPI) steady state solution and the CEST sensitivity efficiency‐based optimization approach. Contrast media & molecular imaging 2016;11(5):415-423. https://doi.org/10.1002/cmmi.1699. [doi]
12. Sun PZ. Quasi‐steady state chemical exchange saturation transfer (QUASS CEST) analysis—correction of the finite relaxation delay and saturation time for robust CEST measurement. Magnetic resonance in medicine 2020;85(6):3281-3289. https://doi.org/10.1002/mrm.28653. [doi]
13. Schuenke P, Windschuh J, Roeloffs V, Ladd ME, Bachert P,Zaiss M. Simultaneous mapping of water shift and B1 (WASABI)—application to field‐inhomogeneity correction of CEST MRI data. Magnetic Resonance in Medicine 2017;77(2):571-580. https://doi.org/10.1002/mrm.26133. [doi]
14. Deoni SC, Rutt BK,Peters TM. Rapid combined T1 and T2 mapping using gradient recalled acquisition in the steady state. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine 2003;49(3):515-526. https://doi.org/10.1002/mrm.10407. [doi]
15. Zhang H, Qiu B, Xu J, Chan KW,Huang J. CESTsimu: An open‐source GUI for spectral and spatial CEST simulation. Magnetic Resonance in Medicine 2025;93(6):2595-2609. https://doi.org/10.1002/mrm.30430. [doi]
16. Chen L, Xu H, Gong T, Jin J, Lin L, Zhou Y, Huang J,Chen Z. Accelerating multipool CEST MRI of Parkinson's disease using deep learning–based Z‐spectral compressed sensing. Magnetic Resonance in Medicine 2024;92(6):2616--2630. https://doi.org/10.1002/mrm.30233. [doi]
17. Zhou J, Zaiss M, Knutsson L, Sun PZ, Ahn SS, Aime S, Bachert P, Blakeley JO, Cai K,Chappell MA. Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: application to brain tumors. Magnetic Resonance in Medicine 2022;88(2):546-574. https://doi.org/10.1002/mrm.29241. [doi]
18. Zhou J, Lal B, Wilson DA, Laterra J,Van Zijl PC. Amide proton transfer (APT) contrast for imaging of brain tumors. Magnetic Resonance in Medicine 2003;50(6):1120-1126. https://doi.org/10.1002/mrm.10651. [doi]
19. Jones CK, Huang A, Xu J, Edden RA, Schär M, Hua J, Oskolkov N, Zacà D, Zhou J,McMahon MT. Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7 T. Neuroimage 2013;77:114-124. https://doi.org/10.1016/j.neuroimage.2013.03.047. [doi]
20. Zhang H, Zeng S, Wang J, Cai P, Wang Z, Chen L, Qiu B,Huang J. Double‐Step R1rho‐Based Lorentzian Fitting (DROF): A New CEST Analysis Approach and Its Comparison With Existing Methods. NMR in Biomedicine 2025;38(8):e70082. https://doi.org/10.1002/nbm.70082. [doi]
21. Bie C, van Zijl P, Xu J, Song X,Yadav NN. Radiofrequency labeling strategies in chemical exchange saturation transfer MRI. NMR in Biomedicine 2023;36(6):e4944. https://doi.org/10.1002/nbm.4944. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/669-01-002