431-01-017 / 431-01-017 ISMRM Abstract

Multimodal MRI visualizes Microglial M2 Polarization via the NOD1/RIP2 Pathway in Glioma Progression

Primary: Neuro - Tumors

Secondary: Preclinical Animal & in vitro MR - Biomarkers

431-01-017 · From Microstructure to Metabolism: Next-Generation MRI for Brain Tumors · Tuesday, 12 May, 8:20 AM–9:56 AM · Roof Terrace

Keywords: Glioma Magnetic resonance imaging Microglia Polarization

Accepted

Xiaoli Wang^1,2, Yuxue Luan¹, Miao Yu¹, Haimo Zhang^1,3, Xiaozu Zhang¹, Peilun Xiao⁴, Fenghua Zhou⁵, Tianyu Zhao¹, Peng Wu ⁶, Xizhen Wang²

¹School of Medical Imaging, Shandong Second Medical University, Weifang, China

²Medical Imaging Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China

³Department of Medical Laboratory Animal Center, Shandong Second Medical University, Weifang, China

⁴School of Basic Medicine, Shandong Second Medical University, Weifang, China

⁵Pathology department, Affiliated Hospital of Shandong Second Medical University, Weifang, China

⁶Clinical & Technical Support, Philips Healthcare, Guangzhou, China

Presenting Author: Peng Wu

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. Yasinjan F, Xing Y, Geng H, et al. Immunotherapy: a promising approach for glioma treatment. Front Immunol. 2023; 14: 1255611. PMID: 37744349 [pmid]

2. Tamtaji OR, Razavi ZS, Razzaghi N, Aschner M, Barati E, Mirzaei H. Quercetin and Glioma: Which Signaling Pathways are Involved? Curr Mol Pharmacol. 2022; 15: 962-968. PMID: 34283340 [pmid]

3. Jiao J, Liu J, Li Q, et al. Gut Microbiota-Derived Diaminopimelic Acid Promotes the NOD1/RIP2 Signaling Pathway and Plays a Key Role in the Progression of Severe Acute Pancreatitis. Front Cell Infect Microbiol. 2022; 12: 838340. PMID: 35811665 [pmid]

4. Zhang X, Li X, Yu Y, et al. Giardia lamblia regulates the production of proinflammatory cytokines through activating the NOD2-Rip2-ROS signaling pathway in mouse macrophages. Immunol Cell Biol. 2022; 100: 440-452. PMID: 35366013 [pmid]

5. Zhou Y, Hu L, Tang W, et al. Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism. J Hematol Oncol. 2021; 14: 9. PMID: 33413510 [pmid]

6. Zhang F, Jiang Q, Cai J, et al. Activation of NOD1 on tumor-associated macrophages augments CD8(+) T cell-mediated antitumor immunity in hepatocellular carcinoma. Sci Adv. 2024; 10: eadp8266. PMID: 39356756 [pmid]

7. Zhang L, Min Z, Tang M, Chen S, Lei X, Zhang X. The utility of diffusion MRI with quantitative ADC measurements for differentiating high-grade from low-grade cerebral gliomas: Evidence from a meta-analysis. J Neurol Sci. 2017; 373: 9-15. PMID: 28131237 [pmid]

8. Li X, Guan J, Jiang Z, et al. Microglial Exosome miR-7239-3p Promotes Glioma Progression by Regulating Circadian Genes. Neurosci Bull. 2021; 37: 497-510. PMID: 33528793 [pmid]

9. Wang L, Li C, Zhan H, et al. Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity. Cell Rep Med. 2024; 5: 101533. PMID: 38744278 [pmid]

10. Ni J, Zhang H, Yang Q, et al. Machine-Learning and Radiomics-Based Preoperative Prediction of Ki-67 Expression in Glioma Using MRI Data. Acad Radiol. 2024; 31: 3397-3405. PMID: 38458887 [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/431-01-017