567-05-003 ISMRM Abstract

Preclinical Sequence Optimization for 129Xe HyperCEST MRI Applications Using a Phantom Simulating In Vivo Relaxation Times

Primary: Contrast Mechanisms - Hyperpolarized MR (Gas)

Secondary: Contrast Mechanisms - Novel Contrast Mechanisms

567-05-003 · Novel Contrast Mechanisms I · Wednesday, 13 May, 4:00 PM–4:55 PM · Digital Posters Row H

Keywords: Modelling Phantoms Relaxation times Hyperpolarized 129Xe MRI Xenon

Accepted

Hannah L Gerbeth ^1,2,3, Leonard Bender^1,3, Luca Kempny^1,3, Alexandra Lipka^4,5, Viktoria Bayer^1,3, Samuel Lehr^1,3, Leif Schröder^1,2,3

¹Devision of Translational Molecular Imaging, German Cancer Research Center (DKFZ), Heidelberg, Germany

²Core Center Heidelberg, German Cancer Consortium (DKTK), Heidelberg, Germany

³Department of Physics and Astronomy, Ruprecht Karls University Heidelberg, Heidelberg, Germany

⁴Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

⁵Division of Translational Molecular Imaging, German Cancer Research Center (DKFZ), Heidelberg, Germany

Presenting Author: Hannah L Gerbeth

Synopsis

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References

1. Albert M. S., Cates G. D., Driehuys B., Happer W., Saam B., Springer Jr C. S., Wishnia A, Biological magnetic resonance imaging using laser-polarized 129Xe. Nature. 1994;370:199

2. Schröder L., Lowery T.J., Hilty C., Wemmer D.E., Pines A. Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor. Science. 2006;314(5798):446-9

3. Wilson G.J. , Santyr G.E., Anderson M.E., DeLuca Jr P.M. Longitudinal relaxation times of 129Xe in rat tissue homogenates at 9.4 T. Magn Reson Med. 1999;41(5):933-8

4. Wolber J., Cherubini A., Leach M.O., Bifone A. On the oxygenation-dependent 129Xe T1 in blood. NMR Biomed., 2000;13(4):234–7

5. Xu X., Norquay G., Parnell S.R., Deppe M.H., Ajraoui S., Hashoian R., Marshall H., Griffiths P.D., Parra-Robles J, Wild J.M. Hyperpolarized 129Xe gas lung MRI-SNR and T2* comparisons at 1.5 T and 3 T. Magn Reson Med. 2012;68(6):1900-4

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http://echo.ismrm.org/p/ISMRM2026/567-05-003