Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-01-001 ISMRM Abstract

Multiple-TE Based Blood–Brain-Barrier Water Exchange Time Measurement Using a TE-Resolved 3D TSE Stack-of-Spirals Readout

Primary: Acquisition & Reconstruction - Pulse Sequence Design: Neuro
Secondary: Acquisition & Reconstruction - Image Reconstruction: Non-AI
362-01-001 · Neuro Sequences, Applications, and Traveling Phantoms · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row C
Keywords: Blood brain barrier Spiral acquisition TE-Resolved readout Multiple-TE PCASL
Accepted
Bo Li1, Yiran Li1, Xiao Liang1, Amnah Mahroo2, Manuel Taso3, Marta Vidorreta Díaz de Cerio4, Lucas Lemos Franco1, M. Dylan Tisdall5, Yulin Chang3, Maria Fernandez-Seara6, Matthias Günther2, John Detre5, Ze Wang 1
1Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, United States of America
2Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany
3Siemens Medical Solutions USA, Inc., Malvern, United States of America
4Siemens Healthcare, Madrid, Spain
5University of Pennsylvania, Philadelphia, United States of America
6Clinica Universidad de Navarra, Pamplona, Spain
Presenting Author: Ze Wang

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Gregori J, Schuff N, Kern R, et al. T2-based arterial spin labeling measurements of blood to tissue water transfer in human brain. J Magn Reson Imaging 2013;37(2):332–342. doi:10.1002/jmri.23822. [doi]
2. Ohene Y, Harrison IF, Evans PG, et al. Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI. Magn Reson Med 2021;85(1):326–333. doi:10.1002/mrm.28496. [doi]
3. Wells JA, Siow B, Lythgoe MF, et al. Measuring biexponential transverse relaxation of the ASL signal at 9.4 T to estimate arterial oxygen saturation and the time of exchange of labeled blood water into cortical brain tissue. J Cereb Blood Flow Metab 2013;33(2):215–224.doi:10.1038/jcbfm.2012.156. [doi]
4. Mahroo A, Buck MA, Huber J, et al. Robust Multi-TE ASL-Based Blood-Brain Barrier Integrity Measurements. Front Neurosci 2021;15:719676. doi:10.3389/fnins.2021.719676. [doi]
5. Vidorreta M, Wang Z, Rodriguez I, et al. Comparison of 2D and 3D single-shot ASL perfusion fMRI sequences. Neuroimage 2013;66:662–671. doi:10.1016/j.neuroimage.2012.10.087. [doi]
6. Vidorreta M, Balteau E, Wang Z, et al. Evaluation of segmented 3D acquisition schemes for whole-brain high-resolution arterial spin labeling at 3 T. NMR in biomedicine 2014;27(11):1387–1396. doi:10.1002/nbm.3201 [doi]
7. Chang YV, Vidorreta M, Wang Z, et al. 3D-accelerated, stack-of-spirals acquisitions and reconstruction of arterial spin labeling MRI. Magn Reson Med 2017;78(4):1405–1419. doi:10.1002/mrm.26549. [doi]
8. Vidorreta M, Wang Z, Chang YV, et al. Whole-brain background-suppressed pCASL MRI with 1D-accelerated 3D RARE Stack-Of-Spirals readout. PLoS One 2017;12(8):e0183762. doi:10.1371/journal.pone.0183762. [doi]
9. Huang P, Carlin JD, Alink A, et al. Prospective motion correction improves the sensitivity of fMRI pattern decoding. Hum Brain Mapp 2018;39(10):4018–4031. doi:10.1002/hbm.24228. [doi]
10. Callaghan MF, Josephs O, Herbst M, et al. An evaluation of prospective motion correction (PMC) for high resolution quantitative MRI. Front Neurosci 2015;9:97. doi:10.3389/fnins.2015.00097. [doi]
11. Li B, Li N, Wang Z, et al. Simultaneous multislice EPI prospective motion correction by real-time receiver phase correction and coil sensitivity map interpolation. Magn Reson Med 2023;90(5):1932–1948. doi:10.1002/mrm.29789. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-01-001