Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
562-03-011 ISMRM Abstract

Automatic White Matter Segmentation on Ultra-High Contrast dSIR Images Using nnU-Net

Accepted
Samuel J Porter1,2, Maryam Tayebi2,3, Jiantao Shen3, Paul M Condron2,4, Mark Bydder2, Gil Newburn2, Ben Bristow2,4, Eryn Kwon 2,3, Daniel Cornfeld2,4, Miriam Scadeng4, Tracy R Melzer5, Samantha Holdsworth2,4, Graeme M Bydder2,6
1University of Canterbury, Christchurch, New Zealand
2Mātai Medical Research Institute, Gisborne, New Zealand
3Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
4University of Auckland, Auckland, New Zealand
5School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand
6University of California, San Diego, United States of America
Presenting Author: Eryn Kwon

Synopsis

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References

1. Condron, P., Cornfeld, D. M., Scadeng, M., Melzer, T. R., Newburn, G., Bydder, M., Kwon, E. E., McGeown, J. P., Handsfield, G. G., Emsden, T., Tayebi, M., Holdsworth, S. J., & Bydder, G. M. (2024). Ultra-High Contrast MRI: The Whiteout Sign Shown with Divided Subtracted Inversion Recovery (dSIR) Sequences in Post-Insult Leukoencephalopathy Syndromes (PILS). Tomography, 10(7), 983-1013. https://doi.org/10.3390/tomography10070074 [doi]
2. Condron P, Cornfeld DM, Bydder M, Kwon EE, Whitehead K, Pravatà E, Danesh-Meyer H, Shi C, Emsden TC, Newburn G, Scadeng M, Holdsworth SJ, Bydder GM. Ultra-High Contrast (UHC) MRI of the Brain, Spinal Cord and Optic Nerves in Multiple Sclerosis Using Directly Acquired and Synthetic Bipolar Filter (BLAIR) Images. Diagnostics (Basel). 2025 Jan 30;15(3):329. doi: 10.3390/diagnostics15030329. PMID: 39941259; PMCID: PMC11816702. [doi] [pmid]
3. Condron, P., Cornfeld, D., Bydder, M., Emsden, T., Newburn, G., Holdsworth, S. J., & Bydder, G. (2025, May). Ultra-High Contrast (UHC) MRI of white matter surrounding cerebral tumours using divided subtracted inversion recovery sequences [Conference abstract]. In Proceedings of the 2025 ISMRM & ISMRT Annual Meeting & Exhibition (Abstract 2381), Hawai, United States. International Society for Magnetic Resonance in Medicine. https://archive.ismrm.org/2025/2381.html
4. Isensee, F., Jaeger, P.F., Kohl, S.A.A. et al. nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation. Nat Methods 18, 203–211 (2021). https://doi.org/10.1038/s41592-020-01008-z [doi]

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