Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
569-04-013 ISMRM Abstract

Comparison of pulse sequences for downfield MR spectroscopic imaging in the human brain at 7T

Primary: Physics & Engineering - High-Field MRI
Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
569-04-013 · Spectroscopy: Acquisition and Reconstruction · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row J
Keywords: 7T Human brain Ultrahigh-field MRI Pulse sequence developoment Downfield MR spectroscopic imaging
Accepted
İpek Özdemir1,2, David J Unobskey3, Adrian G Paez1,3, Moyoko Tomiyasu 1, Joseph Gillen1,3, Sandeep Ganji4, Roland Kreis5,6, Peter B Barker1,3
1Johns Hopkins University School of Medicine, Baltimore, United States of America
2Department of Biomedical Engineering, Johns Hopkins University, Baltimore, United States of America
3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, United States of America
4Philips Healthcare, Best, Netherlands
5Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland
6Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Switzerland
Presenting Author: Moyoko Tomiyasu

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References

1. Özdemir, İ., Etyemez, S., Barker, P. B. Amide mapping in the human brain using downfield MRSI at 3T and 7T. Magn Reson Med. 93:2254–2262 (2025). https://doi.org/10.1002/mrm.30458 [doi]
2. Povazan, M., Schar, M., Gillen, J., Barker, P. B. Magnetic resonance spectroscopic imaging of downfield proton resonances in the human brain at 3 T. Magn Reson Med 87, 1661–1672 (2022). https://doi.org/10.1002/mrm.29142 [doi]
3. Özdemir, İ., Etyemez, S., Barker, P. B. High-field downfield MR spectroscopic imaging in the human brain. Magn Reson Med. 92, 890–899 (2024). https://doi.org/10.1002/mrm.30075 [doi]
4. Geen H. and Freeman R. Band-Selective Radiofrequency Pulses. Journal of Magnetic Resonance 93, 93- 14 1 (1991). https://doi.org/10.1016/0022-2364(91)90034-q [doi]
5. Wilson N.E. , Elliott M.A., Nanga R.P.R., Swago S.,Witschey W.R., Reddy R. Optimization of 1H-MRS methods for large-volume acquisition of low-concentration downfield resonances at 3 T and 7 T Magn Reson Med. 93:18–30 (2025). https://doi.org/10.1002/mrm.30273 [doi]
6. Shemesh N., Dumez J.N., Frydman L. Longitudinal Relaxation Enhancement in 1H NMR Spectroscopy of Tissue Metabolites via Spectrally Selective Excitation Chem. Eur. J. 19, 13002 – 13008 (2013). https://doi.org/10.1002/chem.201300955 [doi]
7. MacMillan E.L., Chong D.G.Q., Dreher W., Henning A., Boesch C., Kreis R. Magnetization Exchange With Water and T1 Relaxation of the Downfield Resonances in Human Brain Spectra at 3.0 T Magn Reson Med. 65:1239–1246 (2011). https://doi.org/10.1002/mrm.22813 [doi]

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http://echo.ismrm.org/p/ISMRM2026/569-04-013