Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
301-03-006 ISMRM Abstract

The Role of AIM2-mediated PANoptosis in Cerebral Ischemia/Reperfusion Injury: A Multimodal MRI Study of the Ischemic Penumbra

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods
Secondary: Neuro - Stroke and Cerebrovascular Disorders
301-03-006 · Neuroimaging and Spectroscopy in Experimental Models · Monday, 11 May, 1:50 PM–3:40 PM · Hall 1A
Keywords: Diffusion-Weighted Imaging Chemical exchange saturation transfer Cerebral ischemia reperfusion injury Ischemic penumbra PANoptosis
Accepted
Xiaoli Wang1,2, Haimo Zhang1,3, Xiaozu Zhang1, Youcheng Qin1, Zhigang Yang1, Chen Li1,4, Zhen Li2, Xizhen Wang2, Peng Wu 5
1School of Medical Imaging, Shandong Second Medical University, Weifang, China
2Medical Imaging Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China
3Department of Medical Laboratory Animal Center, Shandong Second Medical University, Weifang, China
4School of Medicine, Qingdao Binhai University, Qingdao, China
5Clinical & Technical Support, Philips Healthcare, Guangzhou, China
Presenting Author: Peng Wu

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References

1. Qin C, Yang S, Chu YH, et al. Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions [J]. Signal Transduct Target Ther, 2022, 7(1): 215.PMID:35794095. [pmid]
2. Chalet L, Boutelier T, Christen T, et al. Clinical Imaging of the Penumbra in Ischemic Stroke: From the Concept to the Era of Mechanical Thrombectomy [J]. Front Cardiovasc Med, 2022, 9: 861913. PMID:35355966. [pmid]
3. Heo HY, Tee YK, Harston G, et al. Amide proton transfer imaging in stroke [J]. NMR Biomed, 2023, 36(6): e4734.PMID:35322482. [pmid]
4. Ermine CM, Bivard A, Parsons MW, et al. The ischemic penumbra: From concept to reality [J]. Int J Stroke, 2021, 16(5): 497-509.PMID:33818215. [pmid]
5. Heo HY, Zhang Y, Burton TM, et al. Improving the detection sensitivity of pH-weighted amide proton transfer MRI in acute stroke patients using extrapolated semisolid magnetization transfer reference signals [J]. Magn Reson Med, 2017, 78(3): 871-80.PMID:28639301. [pmid]
6. Msayib Y, Harston GWJ, Tee YK, et al. Quantitative CEST imaging of amide proton transfer in acute ischaemic stroke [J]. Neuroimage Clin, 2019, 23: 101833.PMID:31063943. [pmid]
7. Zhang Y, Chen Q, Chen D, et al. SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation [J]. CNS Neurosci Ther, 2022, 28(4): 566-79.PMID:34897996. [pmid]
8. Yao D, Zhang S, Hu Z, et al. CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation [J]. Aging (Albany NY), 2021, 13(23): 25564-77.PMID:34905731. [pmid]
9. Liu X, Zhang M, Liu H, et al. Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes [J]. Exp Neurol, 2021, 341: 113700.PMID:33741350. [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/301-03-006