2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
451-02-010 / 451-02-010 ISMRM Abstract

Label-free drug delivery monitoring and therapeutic response prediction in osteosarcoma

Primary: Contrast Mechanisms - CEST / APT / NOE
Secondary: Preclinical Animal & in vitro MR - Probes & Targets
451-02-010 · Advances in Contrast Mechanisms · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
451-02-010 · Advances in Contrast Mechanisms · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
Keywords: MRI Osteosarcoma Drug monitoring Label-free imaging Therapy effect evaluation
Accepted
Sijie Yuan 1, Qin Yu1, Qingqing Wen2, Yue Yuan1
1Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China(USTC), Hefei, China
2MR Research, Beijing, China
Presenting Author: Sijie Yuan

Synopsis

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References

1. Valle-Inclan, J. E.; De Noon, S.; Trevers, K., et al. Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution. Cell. 2025, 188 (2), 352-370. e322. doi: 10.1016/j.cell.2024.12.005 [doi]
2. Meltzer, P. S.; Helman, L. J. New horizons in the treatment of osteosarcoma. New England Journal of Medicine. 2021, 385 (22), 2066-2076. doi: 10.1056/NEJMra2103423 [doi]
3. Zhuang, J.; Liu, X.; Yang, Y., et al. Sulfasalazine, a potent suppressor of gastric cancer proliferation and metastasis by inhibition of xCT: Conventional drug in new use. Journal of Cellular and Molecular Medicine. 2021, 25 (12), 5372-5380. doi: 10.1111/jcmm.16548 [doi]
4. Koppula, P.; Zhuang, L.; Gan, B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein & cell. 2021, 12 (8), 599-620. doi: 10.1007/s13238-020-00789-5 [doi]
5. Longo, D. L.; Carella, A.; Corrado, A., et al. A snapshot of the vast array of diamagnetic CEST MRI contrast agents. NMR in Biomedicine. 2023, 36 (6), e4715. doi: 10.1002/nbm.4715 [doi]

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http://echo.ismrm.org/p/ISMRM2026/451-02-010