468-01-005 ISMRM Abstract

Imaging–Transcriptomic Decoding of Cortical Reorganization in SCA3 Using MIND Networks

Primary: Neuro - Other Neurodegeneration

Secondary: Analysis Methods - Data Processing

468-01-005 · Quantitative Neuroimaging of Neurodegeneration, Metabolism, and Brain Microstructure · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row I

Keywords: SCA3 MIND networks AHBA gene expression

Accepted

Xingang Wang ^1,2, Yi-Cheng Hsu³, Chen Liu¹

¹7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China

²College of Artificial Intelligence Medicine, Chongqing Medical University, Chongqing 400016, P.R. China, China

³MR Research Collaboration Team, Shanghai, China

Presenting Author: Xingang Wang

Synopsis

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References

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3. Anderson SR, Roberts JM, Ghena N, Irvin EA, Schwakopf J, Cooperstein IB, Bosco A, Vetter ML: Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. Elife 2022, 11.

4. Arnatkeviciute A, Fulcher BD, Bellgrove MA, Fornito A: Imaging Transcriptomics of Brain Disorders. Biol Psychiatry Glob Open Sci 2022, 2:319-331.

5. Martins D, Giacomel A, Williams SCR, Turkheimer F, Dipasquale O, Veronese M: Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain. Cell Rep 2021, 37:110173.

6. Romero-Garcia R, Whitaker KJ, Váša F, Seidlitz J, Shinn M, Fonagy P, Dolan RJ, Jones PB, Goodyer IM, Bullmore ET, Vértes PE: Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex. Neuroimage 2018, 171:256-267.

7. Sebenius I, Seidlitz J, Warrier V, Bethlehem RAI, Alexander-Bloch A, Mallard TT, Garcia RR, Bullmore ET, Morgan SE: Robust estimation of cortical similarity networks from brain MRI. Nat Neurosci 2023, 26:1461-1471.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/468-01-005