Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
468-01-010 ISMRM Abstract

Sub-voxel QSM Reveals Differential Iron and Myelin Pathology in Pre-diabetes and T2DM Cognitive Dysfunction

Primary: Neuro - Other Neurodegeneration
Secondary: Acquisition & Reconstruction - Quantitative Imaging: head and neck
468-01-010 · Quantitative Neuroimaging of Neurodegeneration, Metabolism, and Brain Microstructure · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row I
Keywords: Myelin Type 2 diabetes mellitus Quantitative Susceptibility Mapping (QSM) Iron deposition Sub-voxel QSM
Accepted
Jiali Liang 1, Muliang Jiang1, Bin Tian2, Xi Deng1, Haifeng Zheng1, Hui Zhang3, Xingye Yang1, Rong Wang1
1The First Affiliated Hospital of Guangxi Medical University,, Nanning, China
2Department of Radiology, The Second People's Hospital of Guiyang, Guiyang, China
3MR Research Collaboration Team, Shanghai, China
Presenting Author: Jiali Liang

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References

1. Hu B, Yan LF, Sun Q, et al. Disturbed neurovascular coupling in type 2 diabetes mellitus patients: Evidence from a comprehensive fMRI analysis. Neuroimage Clin. 2019;22:101802.doi:10.1016/j.nicl.2019.101802 [doi]
2. Langkammer C, Schweser F, Krebs N, et al. Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study. Neuroimage. 2012;62(3):1593-1599. doi:10.1016/j.neuroimage.2012.05.049 [doi]
3. Li G, Wu R, Tong R, et al. Quantitative Measurement of Metal Accumulation in Brain of Patients With Wilson's Disease. Mov Disord. 2020;35(10):1787-1795. doi:10.1002/mds.28141 [doi]
4. Bulk M, Abdelmoula WM, Geut H, et al. Quantitative MRI and laser ablation-inductively coupled plasma-mass spectrometry imaging of iron in the frontal cortex of healthy controls and Alzheimer's disease patients. Neuroimage. 2020;215:116808. doi:10.1016/j.neuroimage.2020.116808 [doi]
5. Huang W, Sweeney EM, Kaunzner UW, Wang Y, Gauthier SA, Nguyen TD. Quantitative susceptibility mapping versus phase imaging to identify multiple sclerosis iron rim lesions with demyelination. J Neuroimaging. 2022;32(4):667-675. doi:10.1111/jon.12987 [doi]
6. Li Z, Feng R, Liu Q, et al. APART-QSM: An improved sub-voxel quantitative susceptibility mapping for susceptibility source separation using an iterative data fitting method. Neuroimage. 2023;274:120148. doi:10.1016/j.neuroimage.2023.120148 [doi]
7. Sui C, Li M, Zhang Q, et al. Increased brain iron deposition in the basial ganglia is associated with cognitive and motor dysfunction in type 2 diabetes mellitus. Brain Res. 2025;1846:149263. doi:10.1016/j.brainres.2024.149263 [doi]

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http://echo.ismrm.org/p/ISMRM2026/468-01-010