552-01-005 / 552-01-005 ISMRM Abstract

Towards Dynamic MRSI at 10.5 Tesla: Analysis of Intra-Session Stability for Neurochemical Imaging

Primary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging

Secondary: Physics & Engineering - High-Field MRI

552-01-005 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2

Keywords: 3D magnetic resonance spectroscopic imaging Functional spectroscopy Ultra high field MRI Functional glutamate mapping Dynamic MR Spectroscopy

Accepted

Lukas Hingerl ¹, Bernhard Strasser¹, Simon Schmidt², Korbinian Eckstein¹, Edward J Auerbach³, Andrew Wright⁴, Fabian Niess¹, Pascal Baltzer^1,5, Wolfgang Bogner^1,6, Malgorzata Marjanska³

¹Medical University of Vienna, Vienna, Austria

²Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

³Center for Magnetic Resonance Research, Dept. of Radiology, University of Minnesota, Minneapolis, United States of America

⁴University of Texas Southwestern Medical Center, Dallas, United States of America

⁵Christian Doppler Laboratory for Patient-Centered Breast Imaging, Medical University of Vienna, Vienna, Austria

⁶Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria

Presenting Author: Lukas Hingerl

Synopsis

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References

1. Maudsley AA, Andronesi OC, Barker PB, Bizzi A, Bogner W, Henning A, Nelson SJ, Posse S, Shungu DC, Soher BJ. Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations. NMR Biomed. 2021 May;34(5):e4309. doi: 10.1002/nbm.4309. Epub 2020 Apr 29. PMID: 32350978; PMCID: PMC7606742. [doi] [pmid]

2. Pohmann R, Speck O, Scheffler K. Signal-to-noise ratio and MR tissue parameters in human brain imaging at 3, 7, and 9.4 tesla using current receive coil arrays. Magn Reson Med. 2016 Feb;75(2):801-9. doi: 10.1002/mrm.25677. Epub 2015 Mar 29. PMID: 25820458. [doi] [pmid]

3. Functional spectroscopic imaging (fMRSI) detects metabolite changes in the activated primary sensorimotor cortex at 7T, Petr Bednarik1, Lukas Hingerl1, Dario Goranovic1, Alena Svatkova1, Pedro de Lima Cardoso1, Siegfried Trattnig1, Rupert Lanzenberger2, and Wolfgang Bogner1 https://cds.ismrm.org/protected/20MProceedings/PDFfiles/0381.html

4. Bednarik P, Goranovic D, Svatkova A, Niess F, Hingerl L, Strasser B, Deelchand DK, Spurny-Dworak B, Krssak M, Trattnig S, Hangel G, Scherer T, Lanzenberger R, Bogner W. 1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain. Nat Biomed Eng. 2023 Aug;7(8):1001-1013. doi: 10.1038/s41551-023-01035-z. Epub 2023 Apr 27. PMID: 37106154; PMCID: PMC10861140. [doi] [pmid]

5. Niess F, Strasser B, Hingerl L, Niess E, Motyka S, Hangel G, Krššák M, Gruber S, Spurny-Dworak B, Trattnig S, Scherer T, Lanzenberger R, Bogner W. Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (2H) and indirect (1H) detection of deuterium labeled compounds at 7T and clinical 3T. Neuroimage. 2023 Aug 15;277:120250. doi: 10.1016/j.neuroimage.2023.120250. Epub 2023 Jul 4. PMID: 37414233; PMCID: PMC11019874. [doi] [pmid]

6. Hingerl L, Strasser B, Schmidt S, Eckstein K, Genovese G, Auerbach EJ, Grant A, Waks M, Wright A, Lazen P, Sadeghi-Tarakameh A, Hangel G, Niess F, Eryaman Y, Adriany G, Metzger G, Bogner W, Marjańska M. Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging. Neuroimage. 2025 Feb 15;307:121015. doi: 10.1016/j.neuroimage.2025.121015. Epub 2025 Jan 9. PMID: 39793640; PMCID: PMC11906155. [doi] [pmid]

7. Waks M, Lagore RL, Auerbach E, Grant A, Sadeghi-Tarakameh A, DelaBarre L, Jungst S, Tavaf N, Lattanzi R, Giannakopoulos I, Moeller S, Wu X, Yacoub E, Vizioli L, Schmidt S, Metzger GJ, Eryaman Y, Adriany G, Uğurbil K. RF coil design strategies for improving SNR at the ultrahigh magnetic field of 10.5T. Magn Reson Med. 2025 Feb;93(2):873-888. doi: 10.1002/mrm.30315. Epub 2024 Oct 16. PMID: 39415477; PMCID: PMC11604834. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-01-005