362-04-001 ISMRM Abstract

Quantitative Measurements of Metabolite R₁ρ and R₂ρ Relaxations in the Human Brain at 3 Tesla

Primary: Contrast Mechanisms - Relaxometry

Secondary: Contrast Mechanisms - Spectroscopy

362-04-001 · Spectroscopy and Spectroscopic Imaging: Neuro I · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row C

Keywords: Brain Spectroscopy Relaxation times Human brain Relaxation rates

Accepted

Dinesh K Deelchand ¹, Silvia Mangia¹, Shalom Michaeli¹

¹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, United States of America

Presenting Author: Dinesh K Deelchand

Synopsis

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References

1. Mangia S et al. Rotating frame relaxation during adiabatic pulses vs. conventional spin lock: simulations and experimental results at 4 T Magn Reson Imaging. 2009 Oct;27(8):1074-87. doi: 10.1016/j.mri.2009.05.023 [doi]

2. Gilani et Sepponen Quantitative rotating frame relaxometry methods in MRI. NMR Biomed. 2016 Jun;29(6):841-61. doi: 10.1002/nbm.3518. [doi]

3. Kettunen M et al. Quantitative T1rho NMR spectroscopy of rat cerebral metabolites in vivo: effects of global ischemia. Magn Reson Med 2004 May;51(5):875-80. doi: 10.1002/mrm.20099. [doi]

4. Mangia S et al. Frequency offset dependence of adiabatic rotating frame relaxation rate constants: relevance to MRS investigations of metabolite dynamics in vivo. NMR Biomed. 2011 Aug;24(7):807-14. DOI: 10.1002/nbm.1626 [doi]

5. Deelchand DK et al. Effect of Carr-Purcell refocusing pulse trains on transverse relaxation times of metabolites in rat brain at 9.4 Tesla Magn Reson Med. 2015 Jan;73(1):13-20. doi: 10.1002/mrm.25088. [doi]

6. Deelchand DK et al. Improved localization, spectral quality, and repeatability with advanced MRS methodology in the clinical setting. Magn Reson Med. 2018 Mar;79(3):1241-1250. doi: 10.1002/mrm.26788. [doi]

7. Jokivarsi et al. Quantitative assessment of water pools by T 1 rho and T 2 rho MRI in acute cerebral ischemia of the rat. J Cereb Blood Flow Metab. 2009 Jan;29(1):206-16. doi: 10.1038/jcbfm.2008.113 [doi]

8. Deelchand D. MRspa: Magnetic Resonance signal processing and analysis. Available at: https://www.cmrr.umn.edu/downloads/mrspa/

9. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993. 30(6): 672 – 679. DOI: 10.1002/mrm.1910300604 [doi]

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http://echo.ismrm.org/p/ISMRM2026/362-04-001