Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
661-04-004 ISMRM Abstract

Dynamic modeling of MRI-based tumor habitats during radiotherapy in a murine glioma model

Primary: Analysis Methods - Classification and Prediction
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
661-04-004 · AI-Based Analysis in MR Imaging · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row B
Keywords: Radiotherapy Habitat imaging Multiparametric MRI Mathematical modeling
Accepted
Ayesha Das 1, David A Hormuth, II2,3,4, Jack Virostko3,4,5, Patrik Parker1, Thomas E Yankeelov4
1Biomedical Engineering, The University of Texas at Austin, Austin, United States of America
2The University of Texas at Austin, Austin, United States of America
3Livestrong Cancer Institutes, The University of Texas at Austin, Austin, United States of America
4Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, United States of America
5Dell Medical School, Austin, United States of America
Presenting Author: Ayesha Das

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References

1. Marusyk, A. & Polyak, K. Tumor heterogeneity: Causes and consequences. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1805, 105–117 (2010).
2. Ostrom, Q. T. et al. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010. Neuro-Oncology 15, ii1–ii56 (2013).
3. Yankeelov, T. E., Abramson, R. G. & Quarles, C. C. Quantitative multimodality imaging in cancer research and therapy. Nat Rev Clin Oncol 11, 670–680 (2014).
4. Slavkova, K. P. et al. Mathematical modelling of the dynamics of image-informed tumor habitats in a murine model of glioma. Sci. Rep. 13, (2023).
5. Brüningk, S. C. et al. Intermittent radiotherapy as alternative treatment for recurrent high grade glioma: a modeling study based on longitudinal tumor measurements. Sci Rep 11, 20219 (2021).
6. Hormuth, D. A. Predicting the trajectory of radiotherapy response in patients with head and neck cancer using mathematical modeling of MRI-based habitats. (2025).
7. Hormuth, D. A., Jarrett, A. M. & Yankeelov, T. E. Forecasting tumor and vasculature response dynamics to radiation therapy via image based mathematical modeling. Radiat Oncol 15, 4 (2020).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/661-04-004