Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
469-04-010 ISMRM Abstract

Test-retest reliability of 13C-MRS with an adiabatic excitation pulse to quantify glycogen in human muscle and liver at 7T

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Musculoskeletal - Muscle
469-04-010 · MRI and MRS in Muscle in Health and Disease · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row J
Keywords: Liver Muscle Glycogen 13C Ultra-High Field (UHF)
Accepted
Pandichelvam Veeraiah 1,2, Cas J Fuchs3, Danielle A Blom3, Kim Brouwers1,2, Job van den Hurk1,4, Joachim E Wildberger2,5, Luc J C.Van Loon3, Jeanine J Prompers1,2,3
1Scannexus (Ultra-High Field Imaging Center), Maastricht University, Maastricht, Netherlands
2Maastricht University Medical Center (MUMC+), Maastricht, Netherlands
3Department of Human Biology, NUTRIM Institute for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands
4Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands
5Cardiovascular Research Institute Maastricht, (CARIM), Maastricht University, Maastricht, Netherlands
Presenting Author: Pandichelvam Veeraiah

Synopsis

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References

1. Gruetter R, Magnusson I, Rothman DL, et al. Validation of 13C NMR measurements of liver glycogen in vivo. Magn Reson Med. 1994;31(6):583-588. doi:10.1002/mrm.1910310602 [doi]
2. Taylor R, Price TB, Rothman DL, et al. Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magn Reson Med. 1992;27(1):13-20. doi:10.1002/mrm.1910270103 [doi]
3. Avison MJ, Rothman DL, Nadel E, et al. Detection of human muscle glycogen by natural abundance 13C NMR. Proc Natl Acad Sci U S A. 1988;85(5):1634-1636. doi:10.1073/pnas.85.5.1634 [doi]
4. Poli S, Emara AF, Lange NF, et al. Interleaved trinuclear MRS for single-session investigation of carbohydrate and lipid metabolism in human liver at 7T. NMR Biomed. 2024;37(8):e5123. doi:10.1002/nbm.5123 [doi]
5. Heinicke K, Dimitrov IE, Romain N, et al. Reproducibility and absolute quantification of muscle glycogen in patients with glycogen storage disease by 13C NMR spectroscopy at 7 Tesla. PloS One. 2014;9(10):e108706. doi:10.1371/journal.pone.0108706 [doi]
6. Fuchs CJ, Veeraiah P, Hermans WJH, et al. Carbohydrate intake of 10 g/kg body mass rapidly replenishes liver, but not muscle glycogen contents, during 12 h of post-exercise recovery in well-trained cyclists. J Physiol. 2025 Aug 20. doi:10.1113/JP289115 [doi]
7. Van Cauteren M, Miot F, Segebarth CM, et al. Excitation characteristics of adiabatic half-passage RF pulses used in surface coil MR spectroscopy. Application to 13C detection of glycogen in the rat liver. Phys Med Biol. 1992;37(5):1055-1064. doi:10.1088/0031-9155/37/5/003 [doi]
8. Bendall MR, Pegg DT. Uniform sample excitation with surface coils for in vivo spectroscopy by adiabatic rapid half passage. J Magn Reson 1969. 1986;67(2):376-381. doi:10.1016/0022-2364(86)90447-6 [doi]
9. Buehler T, Bally L, Dokumaci AS, et al. Methodological and physiological test-retest reliability of (13) C-MRS glycogen measurements in liver and in skeletal muscle of patients with type 1 diabetes and matched healthy controls. NMR Biomed. 2016;29(6):796-805. doi:10.1002/nbm.3531 [doi]
10. Zang LH, Laughlin MR, Rothman DL, et al. 13C NMR relaxation times of hepatic glycogen in vitro and in vivo. Biochemistry. 1990;29(29):6815-6820. doi:10.1021/bi00481a009 [doi]
11. van den Wildenberg L, Gursan A, Seelen LWF, et al. In vivo phosphorus magnetic resonance spectroscopic imaging of the whole human liver at 7 T using a phosphorus whole-body transmit coil and 16-channel receive array: Repeatability and effects of principal component analysis-based denoising. NMR Biomed. 2023;36(5):e4877. doi:10.1002/nbm.4877 [doi]
12. Veeraiah P, Fuchs CJ, Voncken R, et al. Repeatability of 13C-MRS for absolute glycogen content quantification in the human liver and skeletal muscle at 7T. ISMRM 2025. Accessed October 22, 2025. https://archive.ismrm.org/2025/2935.html

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/469-04-010