Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-05-009 ISMRM Abstract

DTI-ALPS revealed glymphatic system dysfunction in patients with insomnia

Primary: Diffusion - DWI/DTI/DKI
Secondary: Neuro - White Matter
460-05-009 · When Brain Clearance Fails: Glymphatic Dysfunction Across Disorders · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row A
Keywords: Diffusion Tensor Imaging Sleep Glymphatic system Insomnia
Accepted
Ruifang Xiong 1, Jiankun Dai2, Ye Wang3, Qingqing Wen2, Xiaoping Tang1
1Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
2MR Research, Beijing, China
3The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Presenting Author: Ruifang Xiong

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References

1. Van Someren EJW. Brain mechanisms of insomnia: new perspectives on causes and consequences. Physiol Rev. 2021;101(3):995-1046. https://doi.org/10.1152/physrev.00046.2019 [doi]
2. Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013; 342(6156):373-7. DOI: 10.1126/science.1241224 [doi]
3. Harrison IF, Ismail O, Machhada A, et al. Impaired glymphatic function and clearance of tau in an Alzheimer's disease model. Brain. 2020;143(8):2576-93. https://doi.org/10.1093/brain/awaa179 [doi]
4. Taoka T, Masutani Y, Kawai H, et al. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. Japanese journal of radiology. 2017;35(4):172-8. https://doi.org/10.1007/s11604-017-0617-z [doi]
5. Taoka T, Ito R, Nakamichi R, et al. Diffusion tensor image analysis along the perivascular space (DTI-ALPS): revisiting the meaning and significance of the method. Magnetic Resonance in Medical Sciences. 2024;23(3):268-90. https://doi.org/10.2463/mrms.rev.2023-0175 [doi]
6. Zheng X, Zhang Z, Liang X, et al. Application of DTI-ALPS index for the analysis of the function of central glymphatic system in patients with chronic insomnia. Radiologic Practice. 2023;38(12):1508-12. DOI: 10.13609/j.cnki.1000-0313.2023.12.003. [doi]
7. Jin Y, Zhang W, Yu M, et al. Glymphatic system dysfunction in middle-aged and elderly chronic insomnia patients with cognitive impairment evidenced by diffusion tensor imaging along the perivascular space (DTI-ALPS). Sleep Med. 2024;115:145-51. https://doi.org/10.1016/j.sleep.2024.01.028 [doi]

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http://echo.ismrm.org/p/ISMRM2026/460-05-009