Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
464-03-012 ISMRM Abstract

3D MR fingerprinting derived quantitative T1 and T2 relaxation maps show abnormalities in ALS

Primary: Neuro - Other Neurodegeneration
Secondary: Acquisition & Reconstruction - Quantitative Imaging: head and neck
464-03-012 · Neurodegenerative Diseases · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row E
Keywords: Magnetic Resoance Fingerprinting Amyotrophic lateral sclerosis Disease progression 3D Magnetic Resonance Fingerprinting (MRF) Neurodegenerative Diseases
Accepted
Xuemei Huang1, Ajay Nemani 2, Jacqueline Chen3,4, Matt Kiczek3, Rebecca Kuenzler3, Yuebing Li3, Mark Lowe2,3,4,5, Stephen E Jones2,4
1Cleveland Clinic Imaging Institute, Cleveland, United States of America
2Diagnostic Radiology, Cleveland Clinic, Cleveland, United States of America
3Cleveland Clinic, Cleveland, United States of America
4Imaging Institute, Cleveland Clinic, Cleveland, United States of America
5Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, United States of America
Presenting Author: Ajay Nemani

Synopsis

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References

1. Ma D, Jiang Y, Chen Y, et al. Fast 3D magnetic resonance fingerprinting for a whole-brain coverage. Magn Reson Med. 2018;79(4):2190-2197. doi:10.1002/mrm.26886 [doi]
2. Ma D, Coppo S, Chen Y, et al. Slice profile and B1 corrections in 2D magnetic resonance fingerprinting. Magn Reson Med. 2017;78(5):1781-1789. doi:10.1002/mrm.26580 [doi]
3. Greve DN, Fischl B. Accurate and robust brain image alignment using boundary-based registration. Neuroimage. 2009;48(1):63-72. doi:10.1016/j.neuroimage.2009.06.060 [doi]
4. Dierksen F, Geibel JS, Albrecht J, et al. T1-relaxation times along the corticospinal tract as a diagnostic marker in patients with amyotrophic lateral sclerosis. Front Neuroimaging. 2025;4:1549727. doi:10.3389/fnimg.2025.1549727 [doi]
5. Harper JG, York EN, Meijboom R, et al. Quantitative T1 brain mapping in early relapsing-remitting multiple sclerosis: longitudinal changes, lesion heterogeneity and disability. Eur Radiol. 2024;34(6):3826-3839. doi:10.1007/s00330-023-10351-6 [doi]
6. Niessen HG, Angenstein F, Sander K, et al. In vivo quantification of spinal and bulbar motor neuron degeneration in the G93A-SOD1 transgenic mouse model of ALS by T2 relaxation time and apparent diffusion coefficient. Exp Neurol. 2006;201(2):293-300. doi:10.1016/j.expneurol.2006.04.007 [doi]
7. Dawe RJ, Bennett DA, Schneider JA, et al. Ex vivo T2 relaxation: associations with age-related neuropathology and cognition. Neurobiol Aging. 2014;35(7):1549-1561. doi:10.1016/j.neurobiolaging.2014.01.144 [doi]
8. Gao J, Okolo O, Siedlak SL, Friedland RP, Wang X. Ferritin is closely associated with microglia in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2024;83(11):917-926. doi:10.1093/jnen/nlae074 [doi]

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http://echo.ismrm.org/p/ISMRM2026/464-03-012