369-05-007 ISMRM Abstract

Improving the precision of hyperpolarized 129Xe MR spectroscopy using heart rate-based spectral averaging

Primary: Body - Lung

Secondary: Contrast Mechanisms - Hyperpolarized MR (Gas)

369-05-007 · Hyperpolarized Gases · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row J

Keywords: Lung Spectroscopy Hyperpolarized Xenon-129 MRI Gas Exchange

Accepted

Seth N Lee ¹, Anna Costelle¹, Suphachart Leewiwatwong², David Mummy^1,3, Bastiaan Driehuys^1,2,3

¹Medical Physics Graduate Program, Duke University, Durham, United States of America

²Department of Biomedical Engineering, Duke University, Durham, United States of America

³Department of Radiology, Duke University, Durham, United States of America

Presenting Author: Seth N Lee

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References

1. Kern AL, Vogel-Claussen J. Hyperpolarized gas MRI in pulmonology. Br J Radiol 2018;91(1084):20170647 doi:10.1259/bjr.20170647. [doi]

2. Mugler JP, 3rd, Altes TA. Hyperpolarized 129Xe MRI of the human lung. J Magn Reson Imaging 2013;37(2):313–331 doi:10.1002/jmri.23844. [doi]

3. Qing K, Ruppert K, Jiang Y, et al. Regional mapping of gas uptake by blood and tissue in the human lung using hyperpolarized xenon-129 MRI. J Magn Reson Imaging 2014;39(2):346–359 doi:10.1002/jmri.24181. [doi]

4. Bier EA, Robertson SH, Schrank GM, et al. A protocol for quantifying cardiogenic oscillations in dynamic (129) Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis. NMR Biomed 2019;32(1):e4029 doi:10.1002/nbm.4029. [doi]

5. Ruppert K, Altes TA, Mata JF, Ruset IC, Hersman FW, Mugler JP, 3rd. Detecting pulmonary capillary blood pulsations using hyperpolarized xenon-129 chemical shift saturation recovery (CSSR) MR spectroscopy. Magn Reson Med 2016;75(4):1771–1780 doi:10.1002/mrm.25794. [doi]

6. Niedbalski PJ, Bier EA, Wang Z, Willmering MM, Driehuys B, Cleveland ZI. Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved (129)Xe MRI. J Appl Physiol (1985) 2020;129(2):218–229 doi:10.1152/japplphysiol.00186.2020. [doi]

7. Costelle A, Lu J, Leewiwatwong S, et al. Combining hyperpolarized (129)Xe MR imaging and spectroscopy to noninvasively estimate pulmonary vascular resistance. J Appl Physiol (1985) 2025;138(3):623–633 doi:10.1152/japplphysiol.00440.2024. [doi]

8. Kaushik SS, Robertson SH, Freeman MS, et al. Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition. Magn Reson Med 2016;75(4):1434–1443 doi:10.1002/mrm.25675. [doi]

9. Niedbalski PJ, Hall CS, Castro M, et al. Protocols for multi-site trials using hyperpolarized (129) Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the (129) Xe MRI clinical trials consortium. Magn Reson Med 2021;86(6):2966–2986 doi:10.1002/mrm.28985. [doi]

10. Niedbalski PJ, Willmering MM, Thomen RP, et al. A single-breath-hold protocol for hyperpolarized (129) Xe ventilation and gas exchange imaging. NMR Biomed 2023;36(8):e4923 doi:10.1002/nbm.4923. [doi]

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http://echo.ismrm.org/p/ISMRM2026/369-05-007