Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
569-04-008 ISMRM Abstract

ABSOLUTE QUANTIFICATION OF CARDIAC ENERGETICS IN HEART FAILURE PATIENTS USING 31P MRS AT 3T

Primary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
Secondary: Cardiovascular - Heart Failure
569-04-008 · Spectroscopy: Acquisition and Reconstruction · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row J
Keywords: Heart Failure B1 correction 31P-MRS Cardiac energetics Absolute quantification
Accepted
Mtendere Manase1,2, Aaron Axford 2, Oliver Rider2, Jennifer Holland2, Ladislav Valkovič2,3
1Department of Oncology, University of Oxford, Oxford, United Kingdom
2Oxford Centre for Clinical MR Research (OCMR), University of Oxford, Oxford, United Kingdom
3Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, Slovakia
Presenting Author: Aaron Axford

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References

1. Henry JA, Couch LS, Rider OJ. Myocardial Metabolism in Heart Failure with Preserved Ejection Fraction. J Clin Med. 2024;13(5):1195. doi:10.3390/jcm13051195 [doi]
2. Graaf RA de. In Vivo NMR Spectroscopy: Principles and Techniques. 3rd ed. Wiley; 2018. Accessed August 14, 2025. https://www.perlego.com/book/992980/in-vivo-nmr-spectroscopy-principles-and-techniques-pdf
3. Alger JR. Quantitative Proton Magnetic Resonance Spectroscopy and Spectroscopic Imaging of the Brain: A Didactic Review. Top Magn Reson Imaging TMRI. 2010;21(2):115-128. doi:10.1097/RMR.0b013e31821e568f [doi]
4. Gabr RE, El-Sharkawy AMM, Schär M, et al. Cardiac work is related to creatine kinase energy supply in human heart failure: a cardiovascular magnetic resonance spectroscopy study. J Cardiovasc Magn Reson. 2018;20:81. doi:10.1186/s12968-018-0491-6 [doi]
5. Frištyk S. Absolute quantification of concentration of heart energetic metabolites using phosphorus MR spectroscopy. Zilinská univerzita v žiline Fakulta elektrotechniky a informačných technológií; 2020.
6. Zhou T, Lau J, Miller J, ChIna N, Randell C, Tyler D. (ISMRM 2020) Multilayer Radiofrequency Coils: A Novel Surface Coil Design for Improved B1+ Efficiency and Signal-to-Noise. Accessed October 28, 2025. https://archive.ismrm.org/2020/4028.html
7. Purvis LAB, Clarke WT, Biasiolli L, Valkovič L, Robson MD, Rodgers CT. OXSA: An open-source magnetic resonance spectroscopy analysis toolbox in MATLAB. PLOS ONE. 2017;12(9):e0185356. doi:10.1371/journal.pone.0185356 [doi]
8. Tyler DJ, Hudsmith LE, Clarke K, Neubauer S, Robson MD. A comparison of cardiac (31)P MRS at 1.5 and 3 T. NMR Biomed. 2008;21(8):793-798. doi:10.1002/nbm.1255 [doi]
9. Beer M, Seyfarth T, Sandstede J, et al. Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31P-SLOOP magnetic resonance spectroscopy. J Am Coll Cardiol. 2002;40(7):1267-1274. doi:10.1016/S0735-1097(02)02160-5 [doi]

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http://echo.ismrm.org/p/ISMRM2026/569-04-008