Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
664-02-001 ISMRM Abstract

Multimodal Neuroimaging Reveals Spatiotemporal Dynamics of Stroke Progression in a Non-Human Primate Model

Primary: Preclinical Animal & in vitro MR - Large Animals, Nonhuman Primates
Secondary: Neuro - Stroke and Cerebrovascular Disorders
664-02-001 · Large Animals · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row E
Keywords: Stroke Diffusion-Weighted Imaging Diffusion Tensor Imaging (DTI) Preclinical Animal Models Macaque brain
Accepted
Ssu-Ju Li 1, Ching-Wen Chang1, Boyi Qu2, Yao-Wen Liang1,3, Cheng-Ru Yang1, Ting-Chieh Chen1, Yu-Qian Ke1, Yi-Duan Chen4, Yi-Ren Lin5, Zhi-Shin Cheng5, You-Yin Chen1,3, Hsin-Yi Lai2
1Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan
2Guangdong Institute of Intelligence Science and Technology, China
3Ph.D. Program In Medical Neuroscience, Taipei Medical University, Taipei, Taiwan
4Department of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan
5School of Gerontology and Long-Term Care, Taipei Medical University, Taipei, Taiwan
Presenting Author: Ssu-Ju Li

Synopsis

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References

1. Feigin, Valery L., et al. "Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019." The Lancet Neurology 20.10 (2021): 795-820. https://doi.org/10.1016/S1474-4422(21)00252-0 [doi]
2. Cook, Douglas J., and Michael Tymianski. "Nonhuman primate models of stroke for translational neuroprotection research." Neurotherapeutics 9.2 (2012): 371-379. https://doi.org/10.1007/s13311-012-0115-z [doi]
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4. Li, Ge, et al. "Comprehensive Assessment of Ischemic Stroke in Nonhuman Primates: Neuroimaging, Behavioral, and Serum Proteomic Analysis." ACS Chemical Neuroscience 15.7 (2024): 1548-1559. https://doi.org/10.1021/acschemneuro.3c00826 [doi]
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7. An, Hongyu, et al. "Signal evolution and infarction risk for apparent diffusion coefficient lesions in acute ischemic stroke are both time-and perfusion-dependent." Stroke 42.5 (2011): 1276-1281. https://doi.org/10.1161/STROKEAHA.110.610501 [doi]
8. Wáng, Yì Xiáng J. "Natural course of apparent diffusion coefficient (ADC) change after brain ischemic stroke: an alternative explanation by the triphasic relationship between T2 and ADC." Quantitative Imaging in Medicine and Surgery 14.12 (2024): 9848. https://doi.org/10.21037/qims-24-2383 [doi]
9. Schlaug, G., et al. "Time course of the apparent diffusion coefficient (ADC) abnormality in human stroke." Neurology 49.1 (1997): 113-119. https://doi.org/10.1212/WNL.49.1.113 [doi]
10. Dmytriw, Adam A., Vijay Sawlani, and Jai Shankar. "Diffusion-weighted imaging of the brain: beyond stroke." Canadian Association of Radiologists Journal 68.2 (2017): 131-146. https://doi.org/10.1016/j.carj.2016.10.001 [doi]
11. Wen, Hongmei, et al. "Correlation of fractional anisotropy with motor recovery in patients with stroke after postacute rehabilitation." Archives of physical medicine and rehabilitation 97.9 (2016): 1487-1495. https://doi.org/10.1016/j.apmr.2016.04.010 [doi]
12. Rosenberg, Gary A., et al. "A multimodal approach to stratification of patients with dementia: selection of mixed dementia patients prior to autopsy." Brain Sciences 9.8 (2019): 187. https://doi.org/10.3390/brainsci9080187 [doi]
13. Zhai, Feifei, et al. "Disrupted white matter integrity and network connectivity are related to poor motor performance." Scientific Reports 10.1 (2020): 18369. https://doi.org/10.1038/s41598-020-75617-1 [doi]
14. Groisser, Benjamin N., et al. "Corticospinal tract diffusion abnormalities early after stroke predict motor outcome." Neurorehabilitation and neural repair 28.8 (2014): 751-760. https://doi.org/10.1177/1545968314521896 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/664-02-001