631-02-004 / 631-02-004 ISMRM Abstract

Generating novel contrast for myocardium assessment with periodic irradiation of RAFF2 pulses

Primary: Contrast Mechanisms - Novel Contrast Mechanisms

Secondary: Contrast Mechanisms - Relaxometry

631-02-004 · Everything About Contrast Mechanism · Thursday, 14 May, 1:40 PM–3:16 PM · Roof Terrace

Keywords: Contrast Mechanisms Preclinical Relaxometry Myocardial infarction Ultrahigh-field MRI

Accepted

Elias Ylä-Herttuala ^1,2, Hanne Laakso¹, Svetlana Laidinen¹, Timo Liimatainen^3,4, Shalom Michaeli⁵

¹A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

²Clinical Radiology Unit, Imaging Center, Kuopio University Hospital, Kuopio, Finland

³Research Unit for Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland

⁴Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

⁵Center for Magnetic Resonance Research, Dept. of Radiology, University of Minnesota, Minneapolis, United States of America

Presenting Author: Elias Ylä-Herttuala

Synopsis

Motivation:

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References

1. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation. 2015 Jan 27;131(4):e29-322. doi: 10.1161/CIR.0000000000000152. Epub 2014 Dec 17. Erratum in: Circulation. 2015 Jun 16;131(24):e535. doi: 10.1161/CIR.0000000000000219. Erratum in: Circulation. 2016 Feb 23;133(8):e417. doi: 10.1161/CIR.0000000000000386. PMID: 25520374. [doi] [pmid]

2. Ertl G, Frantz S. Healing after myocardial infarction. Cardiovasc Res. 2005 Apr 1;66(1):22-32. doi: 10.1016/j.cardiores.2005.01.011. PMID: 15769445. [doi] [pmid]

3. Yla-Herttuala, E., Laidinen, S., Laakso, H. et al. Quantification of myocardial infarct area based on TRAFFn relaxation time maps - comparison with cardiovascular magnetic resonance late gadolinium enhancement, T1ρ and T2 in vivo. J Cardiovasc Magn Reson 20, 34 (2018). https://doi.org/10.1186/s12968-018-0463-x [doi]

4. Ylä-Herttuala, E., Laakso, H., Khan, M., Laidinen, S., Heikura, T., Ylä-Herttuala, S. and Liimatainen, T. (2025), Captur-ing Acute and Subchronic Myocardial Infarct by MRI Rotating Frame Relaxation Times in Mice In and Ex Vivo. NMR in Biomedicine, 38: e70061. https://doi.org/10.1002/nbm.70061 [doi]

5. Ylä-Herttuala, E., Vuorio, T., Kettunen, S. et al. Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance TRAFFn, T1ρ and T2 relaxation times. Sci Rep 13, 1579 (2023). https://doi.org/10.1038/s41598-023-28219-6 [doi]

6. Liimatainen T et al. Capturing exchange using periodic radiofrequency irradiation, Journal of Magnetic Resonance, Volume 296, 2018, Pages 79-84, ISSN 1090-7807, https://doi.org/10.1016/j.jmr.2018.09.001. [doi]

7. Chao FA et al. Existence of Singularities in NMR Relaxation Dispersion Profiles: Implications for Hidden Dynamics. J Am Chem Soc 2024, 146, 24467-24475.

8. Reddy GJ et al. Simultaneous determination of fast and slow dynamics in molecules using extreme CPMG relaxation dispersion experiments. Journal of Biomolecular NMR (2018) 70:1–9.

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http://echo.ismrm.org/p/ISMRM2026/631-02-004