Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-01-012 ISMRM Abstract

Mapping of spatiotemporal perfusion deficits in the spinal cord after injury using IVIM MRI

Primary: Neuro - Spinal Cord
Secondary: Neuro - Head & Neck/ENT
363-01-012 · Neurological Application of Advanced Diffusion and Quantitative MRI · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row D
Keywords: IVIM Spinal Cord Spinal cord injury Neuroimaging Biomarkers Perfusion MRI
Accepted
Anna Lebret1, Simon Levy2,3, Armin Curt1, Virginie Callot2, Patrick Freund1,4, Maryam Seif 1,4
1Balgrist University Hospital, University of Zurich, Zurich, Switzerland
2Aix Marseille Univ, CNRS, CRMBM, Marseille, France
3Siemens Healthineers, Melbourne, Australia
4Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
Presenting Author: Maryam Seif

Synopsis

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References

1. Ahuja, C. S., Schroeder, G. D., Vaccaro, A. R. & Fehlings, M. G. Spinal Cord Injury-What Are the Controversies? Journal of orthopaedic trauma vol. 31 S7–S13 Preprint at https://doi.org/10.1097/BOT.0000000000000943 (2017). [doi]
2. Smith, N. J. et al. Spatiotemporal microvascular changes following contusive spinal cord injury. Front Neuroanat 17, 1152131 (2023).
3. Li, Y. et al. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. 23, 733–741 (2017).
4. Lebret, A. et al. Spinal Cord Blood Perfusion Deficit is Associated with Clinical Impairment after Spinal Cord Injury. J Neurotrauma 42, 280–291 (2025).
5. Le Bihan, D. What can we see with IVIM MRI? Neuroimage 1–12 (2018) doi:10.1016/j.neuroimage.2017.12.062. [doi]
6. Le Bihan, D. IVIM method measures diffusion and perfusion. Diagnostic imaging vol. 12 133,136 Preprint at http://www.ncbi.nlm.nih.gov/pubmed/10149369 (1990). [pmid]
7. Lebret, A. et al. Investigation of perfusion impairment in degenerative cervical myelopathy beyond the site of cord compression. Sci Rep 13, (2023).
8. Lebret, A., Lévy, S., Freund, P., Callot, V. & Seif, M. Test-retest repeatability of intravoxel incoherent motion (IVIM) measurements in the cervical cord. Imaging neuroscience (Cambridge, Mass.) 3, (2025).
9. Kirshblum, S. C. et al. International standards for neurological classification of spinal cord injury: Cases with classification challenges. Journal of Spinal Cord Medicine 37, 120–127 (2014).
10. Lévy, S. et al. Intravoxel Incoherent Motion at 7 Tesla to quantify human spinal cord perfusion: limitations and promises. Magn Reson Med 84, 1198–1217 (2020).
11. De Leener, B. et al. PAM50: Unbiased multimodal template of the brainstem and spinal cord aligned with the ICBM152 space. Neuroimage 165, 170–179 (2018).
12. Freund, P. et al. MRI investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury: a prospective longitudinal study. Lancet Neurol 12, 873–881 (2013).
13. Alizadeh, A., Dyck, S. M. & Karimi-Abdolrezaee, S. Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms. Front Neurol 10, 1–25 (2019).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/363-01-012