Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
368-05-005 ISMRM Abstract

Does Brain Geometry Deform Under Strong Magnetic Fields During MRI? Comparison of Ultra-low-field and High-field Imaging

Primary: Neuro
Secondary: Physics & Engineering - Bioeffects & Magnetic Fields
368-05-005 · All Things RF · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row I
Keywords: Bioeffects & Magnetic Fields Neuro Ultra-Low-Field MRI Morphological features
Accepted
Alex T. L. Leong 1,2, Christopher Man1,2, Yilong Liu3, Yujiao Zhao1,2, Vick Lau1,2, Gilberto K. K. Leung4, Ed X Wu1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China
2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China
3Guangdong-Hongkong-Macau CNS Regeneration Institute, Jinan University, Guangzhou, China
4Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Presenting Author: Alex T. L. Leong

Synopsis

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References

1. Liu, Y., Leong, A.T.L., Zhao, Y., Xiao, L., Mak, H.K.F., Tsang, A.C.O., Lau, G.K.K., Leung, G.K.K. & Wu, E.X. A low-cost and shielding-free ultra-low-field brain MRI scanner. Nat Commun 12, 7238 (2021).
2. Zhao, Y., Ding, Y., Lau, V., Man, C., Su, S., Xiao, L., Leong, A.T.L. & Wu, E.X. Whole-body magnetic resonance imaging at 0.05 Tesla. Science 384, eadm7168 (2024).
3. Su, S., Hu, J., Ding, Y., Zhang, J., Lau, V., Zhao, Y. & Wu, E.X. Ultra-low-field magnetic resonance angiography at 0.05 T: A preliminary study. NMR Biomed 37, e5213 (2024).
4. Su, S., Zhao, Y., Ding, Y., Lau, V., Xiao, L., Leung, G.K.K., Lau, G.K.K., Huang, F., Vardhanabhuti, V., Leong, A.T.L. & Wu, E.X. Ultra-low-field magnetization transfer imaging at 0.055T with low specific absorption rate. Magn Reson Med 92, 2420-2432 (2024).
5. Ding, Y., Vardhanabhuti, V., Huang, F., Xiao, L., Su, S., Hu, J., Zhang, J., Lau, V., Man, C., Zhao, Y., Leong, A.T.L. & Wu, E.X. Ultra-low-field Balanced Steady-state Free Precession MRI at 0.05 Tesla. IEEE Trans Biomed Eng PP(2025).
6. Cooley, C.Z., McDaniel, P.C., Stockmann, J.P., Srinivas, S.A., Cauley, S.F., Sliwiak, M., Sappo, C.R., Vaughn, C.F., Guerin, B., Rosen, M.S., Lev, M.H. & Wald, L.L. A portable scanner for magnetic resonance imaging of the brain. Nat Biomed Eng 5, 229-239 (2021).
7. Kimberly, W.T., Sorby-Adams, A.J., Webb, A.G., Wu, E.X., Beekman, R., Bowry, R., Schiff, S.J., de Havenon, A., Shen, F.X., Sze, G., Schaefer, P., Iglesias, J.E., Rosen, M.S. & Sheth, K.N. Brain imaging with portable low-field MRI. Nat Rev Bioeng 1, 617-630 (2023).
8. O'Reilly, T., Teeuwisse, W.M., de Gans, D., Koolstra, K. & Webb, A.G. In vivo 3D brain and extremity MRI at 50 mT using a permanent magnet Halbach array. Magn Reson Med 85, 495-505 (2021).
9. He, Y., He, W., Tan, L., Chen, F., Meng, F., Feng, H. & Xu, Z. Use of 2.1 MHz MRI scanner for brain imaging and its preliminary results in stroke. J Magn Reson 319, 106829 (2020).
10. Sheth, K.N., et al. Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients. JAMA Neurol 78, 41-47 (2020).
11. Mazurek, M.H., et al. Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage. Nat Commun 12, 5119 (2021).
12. Mazurek, M.H., Yuen, M.M., Cahn, B.A., Rosen, M.S., Gobeske, K.T., Gilmore, E.J., Hwang, D., Kaddouh, F., Kim, J.A., Falcone, G., Petersen, N., Siner, J., Spudich, S., Sze, G., Kimberly, W.T. & Sheth, K.N. Low-field, portable magnetic resonance imaging at the bedside to assess brain injury in patients with severe COVID-19 (1349). Neurology 96, 1349 (2021).
13. Yuen, M.M., et al. Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke. Sci Adv 8, eabm3952 (2022).
14. Lau, V., Xiao, L., Zhao, Y., Su, S., Ding, Y., Man, C., Wang, X., Tsang, A., Cao, P., Lau, G.K.K., Leung, G.K.K., Leong, A.T.L. & Wu, E.X. Pushing the limits of low-cost ultra-low-field MRI by dual-acquisition deep learning 3D superresolution. Magn Reson Med 90, 400-416 (2023).
15. Man, C., Lau, V., Su, S., Zhao, Y., Xiao, L., Ding, Y., Leung, G.K.K., Leong, A.T.L. & Wu, E.X. Deep learning enabled fast 3D brain MRI at 0.055 tesla. Sci Adv 9, eadi9327 (2023).
16. Zhao, Y., Xiao, L., Hu, J. & Wu, E.X. Robust EMI elimination for RF shielding-free MRI through deep learning direct MR signal prediction. Magn Reson Med 92, 112-127 (2024).
17. Zhao, Y., Xiao, L., Liu, Y., Leong, A.T. & Wu, E.X. Electromagnetic interference elimination via active sensing and deep learning prediction for radiofrequency shielding-free MRI. NMR Biomed 37, e4956 (2024).
18. Kaye, J.A., DeCarli, C., Luxenberg, J.S. & Rapoport, S.I. The significance of age-related enlargement of the cerebral ventricles in healthy men and women measured by quantitative computed X-ray tomography. J Am Geriatr Soc 40, 225-231 (1992).
19. Bethlehem, R.A.I., et al. Brain charts for the human lifespan. Nature 604, 525-533 (2022).
20. Johnson, P.M. & Lui, Y.W. The deep route to low-field MRI with high potential. Nature 623, 700-701 (2023).
21. Islam, K.T., Zhong, S., Zakavi, P., Chen, Z., Kavnoudias, H., Farquharson, S., Durbridge, G., Barth, M., McMahon, K.L., Parizel, P.M., Dwyer, A., Egan, G.F., Law, M. & Chen, Z. Improving portable low-field MRI image quality through image-to-image translation using paired low- and high-field images. Sci Rep 13, 21183 (2023).
22. Sorby-Adams, A.J., Guo, J., Laso, P., Kirsch, J.E., Zabinska, J., Garcia Guarniz, A.L., Schaefer, P.W., Payabvash, S., de Havenon, A., Rosen, M.S., Sheth, K.N., Gomez-Isla, T., Iglesias, J.E. & Kimberly, W.T. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer's disease. Nat Commun 15, 10488 (2024).
23. Vasa, F., Bennallick, C., Bourke, N.J., Padormo, F., Baljer, L., Briski, U., Cawley, P., Arichi, T., Wood, T.C., Lythgoe, D.J., Dell'Acqua, F., Booth, T.C., Venkataraman, A.V., Ljungberg, E., Deoni, S.C.L., Moran, R.J., Leech, R. & Williams, S.C.R. Ultra-low-field brain MRI morphometry: Test-retest reliability and correspondence to high-field MRI. Imaging Neurosci (Camb) 3, 2024.2008.2014.607942 (2025).
24. Buzsaki, G., Anastassiou, C.A. & Koch, C. The origin of extracellular fields and currents--EEG, ECoG, LFP and spikes. Nat Rev Neurosci 13, 407-420 (2012).
25. Baillet, S. Magnetoencephalography for brain electrophysiology and imaging. Nat Neurosci 20, 327-339 (2017).
26. Pillai, E.K. & Franze, K. Mechanics in the nervous system: From development to disease. Neuron 112, 342-361 (2024).
27. Hall, C.M., Moeendarbary, E. & Sheridan, G.K. Mechanobiology of the brain in ageing and Alzheimer's disease. Eur J Neurosci 53, 3851-3878 (2021).
28. Takamura, T., Motosugi, U., Sasaki, Y., Kakegawa, T., Sato, K., Glaser, K.J., Ehman, R.L. & Onishi, H. Influence of Age on Global and Regional Brain Stiffness in Young and Middle-Aged Adults. J Magn Reson Imaging 51, 727-733 (2020).

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http://echo.ismrm.org/p/ISMRM2026/368-05-005