Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
601-02-003 ISMRM Abstract

Age- and Sex-Dependent Alterations in Skeletal Muscle Microstructure Assessed by DTI and DKI

Primary: Musculoskeletal - Muscle
Secondary: Diffusion - DWI/DTI/DKI
601-02-003 · Muscle MRI in Health and Disease: From Standardization to Application · Thursday, 14 May, 1:40 PM–3:30 PM · Hall 1A
Keywords: DWI/DTI/DKI Musculoskeletal MRI Diffusion kurtosis imaging Sarcopenia MUSCLE AGING
Accepted
Ananya Goyal 1, Donnie Cameron2,3, Luigi Ferrucci3, David A Reiter4, Jelle Veraart5, Valentina Mazzoli6
1Department of Radiology, Stanford University, Stanford, United States of America
2Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands
3Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Maryland, United States of America
4Emory University, Atlanta, United States of America
5Department of Radiology, New York University Langone Health, New York, United States of America
6New York University, New York, United States of America
Presenting Author: Ananya Goyal

Synopsis

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References

1. Cameron D, Reiter DA, Adelnia F, Ubaida-Mohien C, Bergeron CM, Choi S, Fishbein KW, Spencer RG, Ferrucci L. Age-related changes in human skeletal muscle microstructure and architecture assessed by diffusion-tensor magnetic resonance imaging and their association with muscle strength. Aging Cell. 2023 Jul;22(7):e13851. doi: 10.1111/acel.13851. Epub 2023 May 10. PMID: 37162031; PMCID: PMC10352548. [doi] [pmid]
2. Farrow M, Biglands J, Tanner SF, Clegg A, Brown L, Hensor EMA, O'Connor P, Emery P, Tan AL. The effect of ageing on skeletal muscle as assessed by quantitative MR imaging: An association with frailty and muscle strength. Aging Clin Exp Res. 2021 Feb;33(2):291–301. doi: 10.1007/s40520-020-01530-2. Epub 2020 Mar 20. PMID: 32198628; PMCID: PMC7914187. [doi] [pmid]
3. Ferrucci L. The Baltimore Longitudinal Study of Aging (BLSA): A 50-year-long journey and plans for the future. J Gerontol A Biol Sci Med Sci. 2008 Dec;63(12):1416–1419. doi: 10.1093/gerona/63.12.1416. PMID: 19126858; PMCID: PMC5004590. [doi] [pmid]
4. Filli L, Kenkel D, Wurnig MC, Boss A. Diffusional kurtosis MRI of the lower leg: Changes caused by passive muscle elongation and shortening. NMR Biomed. 2016 Jun;29(6):767–775. doi: 10.1002/nbm.3529. Epub 2016 Apr 8. PMID: 27061811. [doi] [pmid]
5. Gudbjartsson H, Patz S. The Rician distribution of noisy MRI data. Magn Reson Med. 1995 Dec;34(6):910–914. doi: 10.1002/mrm.1910340618. Erratum in: Magn Reson Med. 1996 Aug;36(2):332. PMID: 8598820; PMCID: PMC2254141. [doi] [pmid]
6. Mazzoli V, Vainberg Y, Hall ME, Barbieri M, Asay J, Muccini J, Rosenberg J, Kogan F, Delp S, Gold GE. Improved strength prediction combining MRI biomarkers of muscle quantity and quality. NMR Biomed. 2025 Sep;38(9):e70112. doi: 10.1002/nbm.70112. PMID: 40769514. [doi] [pmid]
7. Veraart J, Poot DH, Van Hecke W, Blockx I, Van der Linden A, Verhoye M, Sijbers J. More accurate estimation of diffusion tensor parameters using diffusion kurtosis imaging. Magn Reson Med. 2011 Jan;65(1):138–145. doi: 10.1002/mrm.22603. PMID: 20878760. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/601-02-003