351-02-006 / 351-02-006 ISMRM Abstract

Data-Driven MRI Analysis Reveals Response Phenotypes in Soft Tissue Sarcomas During Neoadjuvant Radiation Therapy

Primary: Musculoskeletal - Other Musculoskeletal

Secondary: Acquisition & Reconstruction - Quantitative Imaging: spine, MSK, others

351-02-006 · MSK: Everything, Everywhere, and All at Once · Monday, 11 May, 1:50 PM–3:26 PM · Power Pitch Theatre 1

Keywords: Biomarker validation Radiation therapy Histology-MRI registration Soft Tissue Sarcoma Treatment Response Assessment

Accepted

Balazs Bogner ¹, Alexander Runkel^2,3, Marco Reisert⁴, Elena Fritsch^1,5, Thierno Diallo¹, Pia M Jungmann¹, Fabian Bamberg^1,5, Matthias Jung¹

¹University Medical Center Freiburg — Department of Diagnostic and Interventional Radiology, Freiburg, Germany

²University Medical Center Freiburg, Freiburg, Germany

³Department of Plastic and Hand Surgery, University Medical Center Freiburg, Freiburg, Germany

⁴University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

⁵Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Freiburg, Germany

Presenting Author: Balazs Bogner

Synopsis

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References

1. Brennan MF, Antonescu CR, Moraco N, Singer S (2014) Lessons learned from the study of 10,000 patients with soft tissue sarcoma. Ann Surg 260:416-421; discussion 421-412. https://doi.org/10.1097/SLA.0000000000000869 [doi]

2. Gronchi A, Miah AB, Dei Tos AP et al (2021) Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 32:1348-1365. https://doi.org/10.1016/j.annonc.2021.07.006 [doi]

3. Gennaro N, van der Loo I, Reijers SJM et al (2025) Heterogeneity in response to neoadjuvant radiotherapy between soft tissue sarcoma histotypes: associations between radiology and pathology findings. Eur Radiol 35:1337-1350. https://doi.org/10.1007/s00330-024-11258-6 [doi]

4. Gennaro N, van der Loo I, Reijers SJM et al (2025) Heterogeneity in response to neoadjuvant radiotherapy between soft tissue sarcoma histotypes: associations between radiology and pathology findings. Eur Radiol 35:1337-1350. https://doi.org/10.1007/s00330-024-11258-6 [doi]

5. Stacchiotti S, Collini P, Messina A et al (2009) High-grade soft-tissue sarcomas: tumor response assessment--pilot study to assess the correlation between radiologic and pathologic response by using RECIST and Choi criteria. Radiology 251:447-456. https://doi.org/10.1148/radiol.2512081403 [doi]

6. Jung M, Bogner B, Diallo TD et al (2023) Multiparametric magnetic resonance imaging for radiation therapy response monitoring in soft tissue sarcomas: a histology and MRI co-registration algorithm. Theranostics 13:1594-1606. https://doi.org/10.7150/thno.81938 [doi]

7. Runkel A, Braig D, Bogner B et al (2023) Non-invasive monitoring of neoadjuvant radiation therapy response in soft tissue sarcomas by multiparametric MRI and quantification of circulating tumor DNA-A study protocol. PLoS One 18:e0285580. https://doi.org/10.1371/journal.pone.0285580 [doi]

8. Soldatos T, Ahlawat S, Montgomery E, Chalian M, Jacobs MA, Fayad LM (2016) Multiparametric Assessment of Treatment Response in High-Grade Soft-Tissue Sarcomas with Anatomic and Functional MR Imaging Sequences. Radiology 278:831-840. https://doi.org/10.1148/radiol.2015142463 [doi]

9. Xia W, Yan Z, Gao X (2017) Volume fractions of DCE-MRI parameter as early predictor of histologic response in soft tissue sarcoma: A feasibility study. Eur J Radiol 95:228-235. https://doi.org/10.1016/j.ejrad.2017.08.021 [doi]

10. Wardelmann E, Haas RL, Bovee JV et al (2016) Evaluation of response after neoadjuvant treatment in soft tissue sarcomas; the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) recommendations for pathological examination and reporting. Eur J Cancer 53:84-95. https://doi.org/10.1016/j.ejca.2015.09.021 [doi]

11. Garner HW, Kransdorf MJ (2016) Musculoskeletal Sarcoma: Update on Imaging of the Post-treatment Patient. Can Assoc Radiol J 67:12-20. https://doi.org/10.1016/j.carj.2014.11.002 [doi]

12. Kakite S, Dyvorne HA, Lee KM, Jajamovich GH, Knight-Greenfield A, Taouli B (2016) Hepatocellular carcinoma: IVIM diffusion quantification for prediction of tumor necrosis compared to enhancement ratios. Eur J Radiol Open 3:1-7. https://doi.org/10.1016/j.ejro.2015.11.002 [doi]

13. van Rijswijk CS, Geirnaerdt MJ, Hogendoorn PC et al (2003) Dynamic contrast-enhanced MR imaging in monitoring response to isolated limb perfusion in high-grade soft tissue sarcoma: initial results. Eur Radiol 13:1849-1858. https://doi.org/10.1007/s00330-002-1785-4 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/351-02-006