666-01-007 ISMRM Abstract

Multicenter evaluation of the POLARIS PHIP polarizer across models and imaging conditions

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Physics & Engineering - New Devices

666-01-007 · Hyperpolarization: Novel Methods · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row G

Keywords: Metabolism Preclinical Hyperpolarized MR (Non-Gas) New Devices Hyperpolarized 13C MRI

Accepted

Vencel Somai ¹, Hadrien Dyvorne¹, Galen Reed¹, Christoph A Müller¹, Catriona Rooney¹, Meret Cepero Malo¹, Andrei Chekushin¹, Senay Karaali¹, Zumrud Ahmodova¹, Martin Grashei¹, Jonas Handwerker¹, Felix Josten¹, Pascal P.R. Ruetten¹, Luca Nagel², Miriam Kirst², Sandra Sühnel², Martin Grashei³, Franz Schilling², Stephen Y Lai⁴, Qing Wang⁴, Yunyun Chen⁴, José S Enriquez⁵, James A Bankson⁶, David Gomez-Cabeza⁷, Lluís Mangas⁷, Gergo Matajsz⁷, Alba Herrero Gómez⁷, Vincent Ribas⁷, Irene Marco-Rius⁸, Renuka Sriram⁹, Dan Vigneron¹⁰, Jeremy W Gordon⁹, Meetu Wadhwa^9,11, Xiao Gao^9,12, Tamara Vasilkovska^9,11,12,13, Max Bullock, rafat chowdhury¹⁴, Shonit Punwani¹⁴, Mario C Chang¹⁵, Saket Patel¹⁶, Roberta Pigliapocchi¹⁶, Thasin Peyear^16,17, Kayvan Keshari¹⁶, Ilai Schwartz¹, Stephan Knecht¹, Myriam Chaumeil^1,12,18

¹NVision Imaging Technologies GmbH, Ulm, Germany

²Technical University of Munich (TUM), Munich, Germany

³Technical University Munich, Munich, Germany

⁴MD Anderson Cancer Center, Houston, United States of America

⁵Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, United States of America

⁶M D Anderson Cancer Center, Houston, United States of America

⁷Institute for Bioengineering of Catalonia, Barcelona, Spain

⁸Molecular Imaging for Precision Medicine, Institute for Bioengineering of Catalonia, Barcelona, Spain

⁹Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America

¹⁰UCSF, San Francisco, United States of America

¹¹University Of California, San Francisco (UCSF), United States of America

¹²Physical Therapy & Rehabilitation Science, University Of California, San Francisco (UCSF), United States of America

¹³Gladstone Institutes, San Francisco, United States of America

¹⁴University College London, London, United Kingdom

¹⁵Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United States of America

¹⁶Memorial Sloan Kettering Cancer Center, New York, United States of America

¹⁷Cornell University, Ithaca, United States of America

¹⁸Ulm University, Ulm, Germany

Presenting Author: Vencel Somai

Synopsis

Motivation:

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References

1. Wang ZJ, Ohliger MA, Larson PE, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB. Hyperpolarized 13C MRI: state of the art and future directions. Radiology. 2019 May;291(2):273-84 doi: 10.1148/radiol.2019182391 [doi]

2. Chaumeil MM, Bankson JA, Brindle KM, Epstein S, Gallagher FA, Grashei M, Guglielmetti C, Kaggie JD, Keshari KR, Knecht S, Laustsen C. New Horizons in Hyperpolarized 13C MRI. Molecular Imaging and Biology. 2024 Apr;26(2):222-32. doi: 10.1007/s11307-023-01888-5 [doi]

3. Nagel L, Gierse M, Gottwald W, Ahmadova Z, Grashei M, Wolff P, Josten F, Karaali S, Müller CA, Lucas S, Scheuer J. Parahydrogen‐Polarized [1‐13C] Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging. Advanced Science. 2023 Oct;10(30):230344 https://doi.org/10.1002/advs.202303441 [doi]

4. Skinner JG, Topping GJ, Nagel L, Heid I, Hundshammer C, Grashei M, van Heijster FHA, Braren R, Schilling F. Spectrally selective bSSFP using off-resonant RF excitations permits high spatiotemporal resolution 3D metabolic imaging of hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion. Magnetic Resonance in Medicine. 2023 Apr;89(4):1768–1781. https://doi.org/10.1002/mrm.29676. [doi]

5. Cavallari, E., Carrera, C., Sorge, M. et al. The 13C hyperpolarized pyruvate generated by ParaHydrogen detects the response of the heart to altered metabolism in real time. Sci Rep 8, 8366 (2018). https://doi.org/10.1038/s41598-018-26583-2 [doi]

6. Oxidation of hyperpolarized [1-13C]pyruvate in isolated rat kidneys Gaurav Sharma, Nesmine Maptue, Mohsin Rahim, Miriam L. Trigo Mijes, Thomas Hever, Xiaodong Wen, Alexander M. Funk, Craig R. Malloy, Jamey D. Young, Chalermchai Khemtong First published: 26 October 2022 https://doi.org/10.1002/nbm.4857 [doi]

7. Choi, YS., Kang, S., Ko, SY. et al. Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet. Mol Brain 11, 74 (2018). https://doi.org/10.1186/s13041-018-0415-2 [doi]

8. Sharma, G., Wu, CY., Wynn, R.M. et al. Real-time hyperpolarized 13C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4–double knockout mouse livers. Sci Rep 9, 16480 (2019). https://doi.org/10.1038/s41598-019-52952-6 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-01-007