Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
631-02-012 / 631-02-012 ISMRM Abstract

Reproducibility, sex and age effects on neuromelanin MRI.

Primary: Neuro - Parkinson's Disease
Secondary: Contrast Mechanisms - Magnetization Transfer
631-02-012 · Everything About Contrast Mechanism · Thursday, 14 May, 1:40 PM–3:16 PM · Roof Terrace
631-02-012 · Everything About Contrast Mechanism · Thursday, 14 May, 1:40 PM–3:16 PM · Roof Terrace
Keywords: Neuromelanin Substantia Nigra Volumetric segmentation Contrast ratio
Accepted
Begona Garate 1,2, Antonio Martín-Bastida1, Marta Vidorreta3, María Cruz Rodríguez-Oroz1, Maria Fernandez-Seara4,5,6,7,8
1Neurology, Clinica Universidad de Navarra, Pamplona, Spain
2Engineering faculty, Universidad de Deusto, Bilbao, Spain
3Siemens Healthcare, Madrid, Spain
4Clinica Universidad de Navarra, Pamplona, Spain
5Navarra Institute for Health Research (IdiSNa), Pamplona, Spain, Spain
6Department of Radiology, Clínica Universidad de Navarra, Spain, Spain
7Navarra Institute for Health Research (IdiSNa), Pamplona, Spain
8Department of Radiology, Clinica Universidad de Navarra, Pamplona, Spain
Presenting Author: Begona Garate

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References

1. He, N., Chen, Y., LeWitt, P. A., Yan, F., & Haacke, E. M. (2023). Application of Neuromelanin <scp>MR</scp> Imaging in Parkinson Disease. Journal of Magnetic Resonance Imaging, 57(2), 337–352. https://doi.org/10.1002/jmri.28414. [doi]
2. Langley, J., Huddleston, D. E., Liu, C. J., & Hu, X. (2017). Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI. Magnetic Resonance Materials in Physics, Biology and Medicine, 30(2), 121–125. https://doi.org/10.1007/s10334-016-0590-z. [doi]
3. Tona, K.-D., Keuken, M. C., de Rover, M., Lakke, E., Forstmann, B. U., Nieuwenhuis, S., & van Osch, M. J. P. (2017). In vivo visualization of the locus coeruleus in humans: quantifying the test–retest reliability. Brain Structure and Function, 222(9), 4203–4217. https://doi.org/10.1007/s00429-017-1464-5. [doi]
4. Xing, Y., Sapuan, A., Dineen, R. A., & Auer, D. P. (2018). Life span pigmentation changes of the substantia nigra detected by neuromelanin‐sensitive MRI. Movement Disorders, 33(11), 1792–1799. https://doi.org/10.1002/mds.27502. [doi]
5. Garate Andikoetxea, B., Martín‐Bastida, A., Vidorreta, M., Rodríguez‐Oroz, M. C., Soustelle, L., Troalen, T., & Fernández‐Seara, M. A. (2025). Neuromelanin Contrast Optimization and Improved Visualization of the Substantia Nigra in a 3D Gradient‐Echo Sequence With Magnetization Transfer. NMR in Biomedicine, 38(9). https://doi.org/10.1002/nbm.70123. [doi]
6. Zecca, L., Gallorini, M., Schünemann, V., Trautwein, A. X., Gerlach, M., Riederer, P., Vezzoni, P., & Tampellini, D. (2001). Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes. Journal of Neurochemistry, 76(6), 1766–1773. https://doi.org/10.1046/j.1471-4159.2001.00186. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/631-02-012