Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-05-002 ISMRM Abstract

129Xe and 1H MRI lung function assessment of PAH associated with systemic sclerosis

Primary: Contrast Mechanisms - Hyperpolarized MR (Gas)
Secondary: Body - Lung
369-05-002 · Hyperpolarized Gases · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row J
Keywords: Lung Hyperpolarized 129Xe MRI Functional lung imaging Pulmonary Imaging Clinical Translation
Accepted
Laura C Saunders 1,2, Guilhem J Collier1, Paul J Hughes1, Scarlett Strickland3, Muad M Almsaaid4, Rebecca Burney3,4, Ian Smith3, Laurie Smith1, Graham Norquay1, Jemima H Pilgrim-Morris1,2, Helen Marshall1,2, Alberto M Biancardi1, Mack Caraher4, Shruti Kulkarni3,4, Felicity Hitchcock3, Neil J Stewart1,2, Andy J Swift3,4, Alexander Rothman3,4, David Kiely3,4, Robin Condliffe3,4, Jim Wild1,2, Roger Thompson3,4
1POLARIS, Division of Clinical Medicine, School of Medicine & Population Health, The University of Sheffield, Sheffield, United Kingdom
2INSIGNEO Institute for In Silico Medicine, The University of Sheffield, Sheffield, United Kingdom
3Sheffield Teaching Hospitals, Sheffield, United Kingdom
4Division of Clinical Medicine, School of Medicine & Population Health, The University of Sheffield, Sheffield, United Kingdom
Presenting Author: Laura C Saunders

Synopsis

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References

1. Bier, E.A., et al., Noninvasive diagnosis of pulmonary hypertension with hyperpolarised (129)Xe magnetic resonance imaging and spectroscopy. ERJ Open Res, 2022. 8(2).
2. Wang, Z.Y., et al., Using hyperpolarized Xe-129 gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity. Journal of Applied Physiology, 2021. 130(5): p. 1398-1409.
3. Stewart, N.J., et al., Experimental validation of the hyperpolarized (129) Xe chemical shift saturation recovery technique in healthy volunteers and subjects with interstitial lung disease. Magn Reson Med, 2015. 74(1): p. 196-207.
4. Collier, G.J., et al., Dissolved (129) Xe lung MRI with four-echo 3D radial spectroscopic imaging: Quantification of regional gas transfer in idiopathic pulmonary fibrosis. Magn Reson Med, 2021. 85(5): p. 2622-2633.
5. Stewart, N.J., et al., Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three-dimensional steady-state free precession. Magn Reson Med, 2015. 74(2): p. 346-52.
6. Chan, H.F., et al., Finite element simulations of hyperpolarized gas DWI in micro-CT meshes of acinar airways: validating the cylinder and stretched exponential models of lung microstructural length scales. Magn Reson Med, 2021. 86(1): p. 514-525.
7. Johnson, K.M., et al., Optimized 3D ultrashort echo time pulmonary MRI. Magn Reson Med, 2013. 70(5): p. 1241-50.
8. Collier, G.J., et al., Age, sex, and lung volume dependence of dissolved xenon-129 MRI gas exchange metrics. Magn Reson Med, 2024. 92(4): p. 1471-1483.
9. Collier, G., Linear binning maps for image analysis of pulmonary ventilation with hyperpolarized gas MRI: transferability and clinical applications. , in International Society for Magnetic Resonance in Medicine. 2018: Paris.
10. Meadus, W.Q., et al., Quantification of lung water density with UTE Yarnball MRI. Magn Reson Med, 2021. 86(3): p. 1330-1344.
11. G. Collier, A.B., H-F Chan, H. Marshall, L. Smith, L. Saunders, N. Stewart, G. Norquay, P. Hughes, J. Wild. Dependence of diffusion and ventilation metrics on hyperpolarized 129Xe lung MRI with demographics in healthy volunteers. in International Society for Magnetic Resonance in Medicine Annual Meeting. 2025. Honolulu, Hawaiʻi, USA.
12. Costelle, A., et al., Combining hyperpolarized (129)Xe MR imaging and spectroscopy to noninvasively estimate pulmonary vascular resistance. J Appl Physiol (1985), 2025. 138(3): p. 623-633.
13. Bier, E.A., et al., A protocol for quantifying cardiogenic oscillations in dynamic (129) Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis. NMR Biomed, 2019. 32(1): p. e4029.
14. Wang, Z., et al., Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures. Eur Respir J, 2019. 54(6).

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http://echo.ismrm.org/p/ISMRM2026/369-05-002