Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
461-05-015 ISMRM Abstract

Early Functional Disruption of Brain Clearance in Sleep Disorders Detected by glymphatic multimodal MRI

Primary: Neuro - Neurofluids
Secondary: Neuro - Other Neurodegeneration
461-05-015 · Advances in Neuroimaging and Biomarkers for Brain Health and Disease · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row B
Keywords: fMRI (resting state) Glymphatic system Cerebrospinal fluid flow Sleep disorders Meningeal lymphatic
Accepted
Jun-Hee Kim 1, Hyochul Lee2, Roh-Eul Yoo2,3,4, Seung Hong Choi2,3,4
1Medical Research Center, Seoul National University, Seoul, Korea, Republic of
2Department of Radiology, Seoul National University College of Medicine, Seoul, Korea, Republic of
3Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of
4Seoul National University College of Medicine, Seoul, Korea, Republic of
Presenting Author: Jun-Hee Kim

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References

1. [1] Fultz, Nina E., et al. "Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep." Science 366.6465 (2019): 628-631. doi: 10.1126/science.aax5440. [doi]
2. [2] Saito, Yuya, et al. "Glymphatic system impairment in sleep disruption: diffusion tensor image analysis along the perivascular space (DTI-ALPS)." Japanese Journal of Radiology 41.12 (2023): 1335-1343. doi: 10.1007/s11604-023-01463-6. [doi]
3. [3] Lee, Min-Hee, et al. "Impact of Sleep Apnea on Perivascular Diffusivity and Cognition: A 4-Year Prospective Cohort Study." American Journal of Respiratory and Critical Care Medicine ja (2025).doi: 10.1164/rccm.202411-2221OC. [doi]
4. [4] Taoka, Toshiaki, et al. "Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases." Japanese journal of radiology 35.4 (2017): 172-178.doi: 10.1007/s11604-017-0617-z. [doi]
5. [5] Saito, Yuya, et al. "Reproducibility of automated calculation technique for diffusion tensor image analysis along the perivascular space." Japanese Journal of Radiology 41.9 (2023): 947-954.doi: 10.1007/s11604-023-01415-0. [doi]
6. [6] Han, Feng, et al. "Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology." PLoS biology 19.6 (2021): e3001233. doi: 10.1371/journal.pbio.3001233. [doi]
7. [7] Kim JH, Yoo RE, Choi SH, Park SH. Non-invasive flow mapping of parasagittal meningeal lymphatics using 2D interslice flow saturation MRI. Fluids Barriers CNS. 2023 May 26;20(1):37. doi: 10.1186/s12987-023-00446-z. [doi]
8. [8] Yoo RE, Kim JH, Moon HY, Park JY, Cheon S, Shin HS, Han D, Kim Y, Park SH, Choi SH. Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans. Nat Commun. 2025 Apr 9;16(1):3360. doi: 10.1038/s41467-025-58726-1. [doi]
9. [9] Kim JH, Im JG, Park SH. Measurement of CSF pulsation from EPI-based human fMRI. Neuroimage. 2022 Aug 15;257:119293. doi: 10.1016/j.neuroimage.2022.119293. Epub 2022 May 10. [doi]
10. [10] Kim JH, Im JG, Park SH. Measurement of changes in cerebrospinal fluid pulsation after traumatic brain injury using echo-planar imaging-based functional MRI. NMR Biomed. 2024 Mar;37(3):e5061. doi: 10.1002/nbm.5061. [doi]
11. [11] Kim JH, Kim S, Im JG, Chung SJ, Lee PH, Jeong Y, Park SH. CSF pulsations measured in Parkinson's disease patients using EPI-based fMRI data. Front Aging Neurosci. 2024;16:1369522. doi: 10.3389/fnagi.2024.1369522. [doi]
12. [12] Boutinaud, Philippe, et al. "3D segmentation of perivascular spaces on T1-weighted 3 Tesla MR images with a convolutional autoencoder and a U-shaped neural network." Frontiers in neuroinformatics 15 (2021): 641600.doi: 10.3389/fninf.2021.641600 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/461-05-015