463-03-004 ISMRM Abstract

Reduced Structural and Perfusion Alterations with Smaller Lesion Volume after Ischemia-Reperfusion Injury in FKBP51 Knockout

Primary: Neuro - Stroke and Cerebrovascular Disorders

Secondary: Analysis Methods - Data Processing

463-03-004 · Metabolic Parameters in Stroke · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row D

Keywords: Acute Ischemic Stroke Voxel-Based Morphometry (VBM) FKBP51 Transient middle cerebral artery occlusion (tMCAO)

Accepted

Sih-Ting Chen ¹, Chia-Feng Lu¹, Yu-Chieh Jill Kao¹

¹Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan

Presenting Author: Sih-Ting Chen

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References

1. Pu, L., et al., Projected Global Trends in Ischemic Stroke Incidence, Deaths and Disability-Adjusted Life Years From 2020 to 2030. Stroke, 2023. 54(5): p. 1330–1339. doi: 10.1161/strokeaha.122.040073 [doi]

2. Sun, M.S., et al., Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy. Oxid Med Cell Longev, 2018. 2018: p. 3804979. doi: 10.1155/2018/3804979 [doi]

3. Ma, R., et al., Animal models of cerebral ischemia: A review. Biomed Pharmacother, 2020. 131: p. 110686. doi: 10.1016/j.biopha.2020.110686 [doi]

4. Engelhardt, C., et al., Lack of FKBP51 Shapes Brain Structure and Connectivity in Male Mice. J Magn Reson Imaging, 2021. 53(5): p. 1358–1365. doi: 10.1002/jmri.27439 [doi]

5. Yu, S., et al., FKBP5 Exacerbates Impairments in Cerebral Ischemic Stroke by Inducing Autophagy via the AKT/FOXO3 Pathway. Front Cell Neurosci, 2020. 14: p. 193. doi: 10.3389/fncel.2020.00193 [doi]

6. Liu, Y., et al., Serial diffusion tensor MRI after transient and permanent cerebral ischemia in nonhuman primates. Stroke, 2007. 38(1): p. 138–45. doi: 10.1161/01.STR.0000252127.07428.9c [doi]

7. Mestre, H., et al., Cerebrospinal fluid influx drives acute ischemic tissue swelling. Science, 2020. 367(6483). doi: 10.1126/science.aax7171 [doi]

8. Song, M. and S.P. Yu, Ionic regulation of cell volume changes and cell death after ischemic stroke. Transl Stroke Res, 2014. 5(1): p. 17–27. doi: 10.1007/s12975-013-0314-x [doi]

9. Wu, C.T., et al., Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model. Molecules, 2022. 27(18). doi: 10.3390/molecules27185783 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/463-03-004