Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
361-03-007 ISMRM Abstract

Towards quantitative cerebrovascular reactivity (CVR) mapping with ultra-fast blood flow imaging

Primary: Contrast Mechanisms - Velocity/Flow
Secondary: Neuro - Blood Vessels
361-03-007 · Thermometry and Other Contrast Mechanisms · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row B
Keywords: Velocity & Flow Cerebrovascular reactivity Cerebral blood flow Real-time phase-contrast MRI
Accepted
Dinil Sasi Sankaralayam 1, Cuimei Xu1, Jiani Wu1,2, Teni Akinwale1,2, Hanzhang Lu1,2,3
1Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, United States of America
2Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, United States of America
3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States of America
Presenting Author: Dinil Sasi Sankaralayam

Synopsis

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References

1. Glodzik L, Randall C, Rusinek H, de Leon MJ. Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease. J Alzheimers Dis. 2013;35:427-440. doi: 10.3233/JAD-122011 [doi]
2. Liu P, Jiang D, Albert M, Bauer CE, Caprihan A, Gold BT, Greenberg SM, Helmer KG, Jann K, Jicha G, et al. Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge. Neuroimage. 2021;245:118754. doi: 10.1016/j.neuroimage.2021.118754 [doi]
3. McKetton L, Sobczyk O, Duffin J, Poublanc J, Sam K, Crawley AP, Venkatraghavan L, Fisher JA, Mikulis DJ. The aging brain and cerebrovascular reactivity. Neuroimage. 2018;181:132-141. doi: 10.1016/j.neuroimage.2018.07.007 [doi]
4. Sankaralayam DS, Xu C, Hu Z, Moghekar A, Jiang D, Hu C, Liu P, Lu H. The dependence of CO2 cerebrovascular reactivity (CVR) on caffeine. Imaging Neuroscience. 2025;3:IMAG. a. 103.
5. Kim D, Hong SY, Hughes TM, Lipford ME, Lockhart SN, Craft S, Baker LD, Whitlow CT, Okonmah‐Obazee SE, Hugenschmidt C. Vascular contribution to the relationship between cerebrovascular reactivity and cognition. Alzheimer's & Dementia. 2023;19:e082688.
6. Sur S, Lin Z, Li Y, Yasar S, Rosenberg PB, Moghekar A, Hou X, Jiang D, Kalyani RR, Hazel K, et al. CO(2) cerebrovascular reactivity measured with CBF-MRI in older individuals: Association with cognition, physical function, amyloid, and tau proteins. J Cereb Blood Flow Metab. 2024:271678X241240582. doi: 10.1177/0271678X241240582 [doi]
7. Sankaralayam DS, Wu J, Xu C, Akinwale T, Liu P, Lu H. Real-time EPI-based phase-contrast MRI for the measurement of cerebrocvascular reactivity, Proc. Intl. Soc. Mag. Reson. Med. 33 (2025). p-2470 .
8. Liu P, Xu C, Lin Z, Sur S, Li Y, Yasar S, Rosenberg P, Albert M, Lu H. Cerebrovascular reactivity mapping using intermittent breath modulation. Neuroimage. 2020;215:116787. doi: 10.1016/j.neuroimage.2020.116787 [doi]
9. Liu P, Baker Z, Li Y, Li Y, Xu J, Park DC, Welch BG, Pinho M, Pillai JJ, Hillis AE, et al. CVR-MRICloud: An online processing tool for CO2-inhalation and resting-state cerebrovascular reactivity (CVR) MRI data. PLoS One. 2022;17:e0274220. doi: 10.1371/journal.pone.0274220 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/361-03-007