Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
430-04-001 ISMRM Abstract

Lipomatous Metaplasia in Hemorrhagic and Nonhemorrhagic Myocardial Infarctions: A PET/MRI Study with Histological Validation

Primary: Cardiovascular - Myocardium
Secondary: Preclinical Animal & in vitro MR - Large Animals, Nonhuman Primates
430-04-001 · Cardiovascular and Body Imaging · Tuesday, 12 May, 4:00 PM–5:50 PM · Meeting Room 2.60
Keywords: Myocardial remodeling Myocardial infarction PET-MRI Iron deposition
Accepted
Joao Pedro Torres Neiva Rodrigues 1, Leon Riehakainen1, Alan C Kwan2,3, Debiao Li1,4, Ivan Cokic1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, United States of America
4Department of Bioengineering, University of California Los Angeles, Los Angeles, United States of America
Presenting Author: Joao Pedro Torres Neiva Rodrigues

Synopsis

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References

1. Mordi, I. et al. Prevalence and Prognostic Significance of Lipomatous Metaplasia in Patients With Prior Myocardial Infarction. JACC Cardiovasc. Imaging 8, 1111–1112 (2015). https://doi.org/10.1016/j.jcmg.2014.07.024 [doi]
2. Ahn, S. S. et al. CT Detection of Subendocardial Fat in Myocardial Infarction. Am. J. Roentgenol. 192, 532–537 (2009). doi: 10.2214/AJR.08.1608. [doi]
3. Xu, L. et al. Lipomatous Metaplasia Facilitates Slow Conduction in Critical Ventricular Tachycardia Corridors Within Postinfarct Myocardium. JACC Clin. Electrophysiol. 9, 1235–1245 (2023). doi: 10.1016/j.jacep.2023.02.014. [doi]
4. Cokic, I. et al. Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium. Nat. Commun. 13, 6394 (2022). doi: 10.1038/s41467-022-33776-x. [doi]
5. Pouliopoulos, J. et al. Intramyocardial Adiposity After Myocardial Infarction. Circulation 128, 2296–2308 (2013). doi: 10.1161/CIRCULATIONAHA.113.002238. [doi]
6. Feng, Y. et al. Lipomatous metaplasia identified in rabbits with reperfused myocardial infarction by 3.0 T magnetic resonance imaging and histopathology. BMC Med. Imaging 13, 18 (2013). doi: 10.1186/1471-2342-13-18. [doi]
7. Li, L. et al. Pitx2 maintains mitochondrial function during regeneration to prevent myocardial fat deposition. Dev. Camb. Engl. 145, dev168609 (2018). doi: 10.1242/dev.168609. [doi]
8. Dilsizian, V. et al. ASNC imaging guidelines/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures. J. Nucl. Cardiol. 23, 1187–1226 (2016). doi: 10.1007/s12350-016-0522-3. [doi]
9. Osborne, M. T. et al. Patient preparation for cardiac fluorine-18 fluorodeoxyglucose positron emission tomography imaging of inflammation. J. Nucl. Cardiol. Off. Publ. Am. Soc. Nucl. Cardiol. 24, 86–99 (2017). doi: 10.1007/s12350-016-0502-7. [doi]
10. Wilk, B. et al. Tracking the progress of inflammation with PET/MRI in a canine model of myocardial infarction. J. Nucl. Cardiol. Off. Publ. Am. Soc. Nucl. Cardiol. 29, 1315–1325 (2022). doi: 10.1007/s12350-020-02487-5. [doi]

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http://echo.ismrm.org/p/ISMRM2026/430-04-001