531-02-003 / 531-02-003 ISMRM Abstract

Triple-Network Effective Connectivity Predicts Dementia Conversion in Cognitively Normal Adults

Primary: Neuro - Dementia

Secondary: Analysis Methods - Classification and Prediction

531-02-003 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace

Keywords: Alzheimer's Disease Dynamic Causal Modelling Functional MRI Functional network connectivity

Accepted

Zhen Xuen Brandon Low¹, Lucy Vivash², Terence J O'Brien^2,3,4, Adeel Razi¹, Meng Law^1,2,5, Ben Sinclair ¹

¹Monash University, Melbourne, Australia

²Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia

³The Alfred, Australia

⁴Neurology, Alfred Hospital, Melbourne, Australia

⁵Alfred Health, Melbourne, Australia

Presenting Author: Ben Sinclair

Synopsis

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References

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6. Wang, X., Shi, Z., Qiu, Y., Sun, D., & Zhou, H. (2024). Peripheral GFAP and NfL as early biomarkers for dementia: longitudinal insights from the UK Biobank. BMC Medicine, 22(1), 192. https://doi.org/10.1186/s12916-024-03418-8 [doi]

7. Almgren, H., Van de Steen, F., Kühn, S., Razi, A., Friston, K., & Marinazzo, D. (2018). Variability and reliability of effective connectivity within the core default mode network: A multi-site longitudinal spectral DCM study. Neuroimage, 183, 757-768. https://doi.org/10.1016/j.neuroimage.2018.08.053 [doi]

8. Dunn, C. J., Duffy, S. L., Hickie, I. B., Lagopoulos, J., Lewis, S. J. G., Naismith, S. L., & Shine, J. M. (2014). Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment. NeuroImage: Clinical, 4, 473-480. https://doi.org/https://doi.org/10.1016/j.nicl.2014.02.010 [doi]

9. Krönke, K. M., Wolff, M., Shi, Y., Kräplin, A., Smolka, M. N., Bühringer, G., & Goschke, T. (2020). Functional connectivity in a triple-network saliency model is associated with real-life self-control. Neuropsychologia, 149, 107667. https://doi.org/10.1016/j.neuropsychologia.2020.107667 [doi]

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http://echo.ismrm.org/p/ISMRM2026/531-02-003