Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
605-03-009 ISMRM Abstract

Gradient Echo with Improved Microstructure-Informed Myelin, Iron and Water Mapping predicts Cognitive Decline in Aging and AD

Accepted
MANXI XU1,2,3, Mert Sisman3,4, Aocai Yang5, Yian Gao1, Peiling Ou5, Pascal Spincemaille 6, Guolin Ma1, Yi Wang 6,7
1Radiology, China-Japan Friendship Hospital, Beijing, China
2Peking University Health Science Center, Beijing, China
3Department of Radiology, Weill Cornell Medicine, Cornell University, New York, United States of America
4Electrical & Computer Engineering, Cornell University, Ithaca, United States of America
5China-Japan Friendship Hospital, Beijing, China
6Department of Radiology, Weill Cornell Medicine, New York, United States of America
7Biomedical Engineering, Cornell University, Ithaca, United States of America
Presenting Author: Yi Wang

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Moreno-Rodriguez M, Perez SE, Malek-Ahmadi M, Mufson EJ. APOEepsilon4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease. J Neuroinflammation. Jan 30 2025;22(1):25. doi:10.1186/s12974-025-03349-y [doi]
2. Li Z, Sun Y, Li T, et al. The impact of amyloid beta burden on white matter dysfunction and associated transcriptomic signatures in cognitively normal elderly individuals. Alzheimers Dement (Amst). Oct-Dec 2025;17(4):e70192. doi:10.1002/dad2.70192 [doi]
3. Krausz C, Bonaccorsi L, Maggio P, et al. Two functional assays of sperm responsiveness to progesterone and their predictive values in in-vitro fertilization. Hum Reprod. Aug 1996;11(8):1661-7. doi:10.1093/oxfordjournals.humrep.a019466 [doi]
4. De Rochefort L, Liu T, Kressler B, et al. Quantitative susceptibility map reconstruction from MR phase data using bayesian regularization: Validation and application to brain imaging. Magnetic Resonance in Medicine. 2010;63(1):194-206. doi:10.1002/mrm.22187 [doi]
5. Liu T, Wisnieff C, Lou M, Chen W, Spincemaille P, Wang Y. Nonlinear formulation of the magnetic field to source relationship for robust quantitative susceptibility mapping. Magnetic Resonance in Medicine. 2013;69(2):467-476. doi:10.1002/mrm.24272 [doi]
6. Liu T, Khalidov I, De Rochefort L, et al. A novel background field removal method for MRI using projection onto dipole fields (PDF). NMR in Biomedicine. 2011;24(9):1129-1136. doi:10.1002/nbm.1670 [doi]
7. Şişman M, Nguyen TD, Roberts AG, et al. Microstructure-Informed Myelin Mapping (MIMM) from routine multi-echo gradient echo data using multiscale physics modeling of iron and myelin effects and QSM. Magn Reson Med. Apr 2025;93(4):1499-1515. doi:10.1002/mrm.30369 [doi]
8. Şişman M, Dimov AV, Spincemaille P, Nguyen TD, Wang Y. Improved Microstructure-Informed Myelin Mapping (iMIMM) for Myelin Mapping solely from Gradient-Echo Data. 2025:
9. Laso P, Cerri S, Sorby-Adams A, et al. Quantifying White Matter Hyperintensity and Brain Volumes in Heterogeneous Clinical and Low-Field Portable Mri. Proc IEEE Int Symp Biomed Imaging. May 2024;2024doi:10.1109/isbi56570.2024.10635502 [doi]
10. Avants BB, Tustison N, Song G. Advanced normalization tools (ANTS). Insight j. 2009;2(365):1-35.
11. Eickhoff SB, Stephan KE, Mohlberg H, et al. A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. Neuroimage. May 1 2005;25(4):1325-35. doi:10.1016/j.neuroimage.2004.12.034 [doi]
12. Sams EC. Oligodendrocytes in the aging brain. Neuronal Signal. Sep 2021;5(3):NS20210008. doi:10.1042/NS20210008 [doi]
13. Nasrabady SE, Rizvi B, Goldman JE, Brickman AM. White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes. Acta Neuropathol Commun. Mar 2 2018;6(1):22. doi:10.1186/s40478-018-0515-3 [doi]
14. Smith KJ, Kapoor R, Felts PA. Demyelination: the role of reactive oxygen and nitrogen species. Brain Pathol. Jan 1999;9(1):69-92. doi:10.1111/j.1750-3639.1999.tb00212.x [doi]

Cite this abstract