Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
503-02-007 ISMRM Abstract

Dual-phase systolic and diastolic cardiac diffusion MRI using higher-order motion compensation at 300 mT/m gradient strength

Primary: Diffusion - Microstructure
Secondary: Cardiovascular - Myocardium
503-02-007 · Body Diffusion MRI · Wednesday, 13 May, 1:40 PM–3:30 PM · Auditorium 1
Keywords: Cardiac MRI Diffusion Tensor Imaging Ultra-strong gradients Diastole Higher order motion compensation
Accepted
Maryam Afzali 1,2,3,4, Irvin Teh3,4, Sam Coveney3, Lars Mueller3, Sarah Jones1, May Lwin3, Fabrizio Fasano5,6, John Evans1, Isaac Watson3, Filip Szczepankiewicz7, Derek K Jones1, Erica Dall’Armellina3, Jurgen E Schneider3
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
2Division of Cardiovascular Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom
3Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom
4These authors contributed equally to this work and share first authorship, University of Leeds, Leeds, United Kingdom
5Siemens Healthcare Ltd., Camberly, United Kingdom
6Siemens Healthcare GmbH, Erlangen, Germany
7Department of Medical Radiation Physics, Lund, Sweden, Lund University, Lund, Sweden
Presenting Author: Maryam Afzali

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References

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2. Chen J, Liu W, Zhang H, Lacy L, Yang X, Song SK, et al. Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI. Am J Physiol Heart Circ Physiol [Internet]. 2005;289:1898–907. PMID: 16219812 [pmid]
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4. Cheng YJ, Lang D, Caruthers SD, Efimov IR, Chen J, Wickline SA. Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts. Am J Physiol Heart Circ Physiol [Internet]. 2012;303:559–68. PMID: 22777417 [pmid]
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7. Teh I, Coveney S, Foster RJ, Szczepankiewicz F, Lasic S, Lundell H, et al. Time-dependent Diffusion in the Human Heart In Vivo. ISMRM. 2023;
8. Coveney S, Afzali M, Foster RJ, Mueller L, Sharrak N, Yuldasheva NY, et al. Snap, Crackle And Pop: Benefits of Serial Motion Compensation in Cardiac Diffusion Tensor Imaging. ISMRM. 2024;
9. Afzali M, Mueller L, Coveney S, Fasano F, Evans CJ, Engel M, et al. In vivo diffusion MRI of the human heart using a 300 mT/m gradient system. Magn Reson Med. 2024 Sep 1;92(3):1022–34. PMID: 38650395 [pmid]
10. Wen K, Wage R, Ferreira P, Kunze KP, Pennell D, Scott AD, et al. Comparative evaluation of third-order motion-compensated in vivo diffusion tensor CMR across cardiac phases using an ultra-high-gradient strength clinical scanner. Journal of Cardiovascular Magnetic Resonance. 2025 Spring;27:101266.
11. Mueller L, Afzali M, Coveney S, Doring A, Fasano F, Evans J, et al. ZOOM and enhance: Zonally magnified Oblique Multi-slice for cardiac DTI with ultra-strong gradients. Proceedings of the Annual Meeting of ISMRM. 2024;
12. Szczepankiewicz F, Sjölund J, Ståhlberg F, Lätt J, Nilsson M. Tensor-valued diffusion encoding for diffusional variance decomposition (DIVIDE): Technical feasibility in clinical MRI systems. PLoS One. 2019;14(3). PMID: 30921381 [pmid]
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15. Coveney S, Afzali M, Mueller L, Teh I, Das A, Dall’Armellina E, et al. Outlier detection in cardiac diffusion tensor imaging: Shot rejection or robust fitting? Med Image Anal. 2025 Apr 1;101. PMID: 39667253 [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/503-02-007