Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
452-02-014 / 452-02-014 ISMRM Abstract

Decoupling of Optic-Radiation Pathways and Frontal Upregulation in Late-Onset Blindness: A 7T rs-fMRI Study

Accepted
Yuqi WANG 1,2, Jinhao Lyu3,4, Shengshu Sun1, Bin Ruan1, Youhan Ao2, Weijia Wang2, Wanping Hu1, Liqiang Wang5, Xin Lou3,5
1Chinese PLA General Hospital, Beijing, China
2Nankai University, Tianjin, China
3Department of Radiology, The First Medical Center, Chinese PLA General Hospital, Beijing, China
4radiology, Chinese PLA General Hospital, Beijing, China
5The First Medical Center, Chinese PLA General Hospital, Beijing, China
Presenting Author: Yuqi WANG

Synopsis

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References

1. Wade AR, Wandell BA. Chromatic light adaptation measured using functional magnetic resonance imaging. J Neurosci. 2002;22(18):8148‑8157. doi:10.1523/JNEUROSCI.22-18-08148.2002 [doi]
2. Fine I, Park JM. Vision and the functional architecture of the human brain: neural plasticity and adaptation. Annu Rev Vis Sci. 2018;4:337‑356. doi:10.1146/annurev‑vision‑102016‑061241 [doi]
3. Wandell BA, Smirnakis SM. Plasticity and stability of visual field maps in adult primary visual cortex. Nat Rev Neurosci. 2009;10(12):873‑884. doi:10.1038/nrn2741 [doi]
4. Kupers R, Ptito M. Compensatory plasticity and cross‑modal reorganization following early visual deprivation. Neurosci Biobehav Rev. 2014;41:36‑52. doi:10.1016/j.neubiorev.2013.08.001 [doi]
5. Sadato N, Pascual‑Leone A, Grafman J, Ibañez V, Deiber MP, Dold G, Hallett M. Activation of the primary visual cortex by Braille reading in blind subjects. Nature. 1996;380(6574):526‑528. doi:10.1038/380526a0 [doi]
6. Paré M, Bleau MM, Dricot L, Ptito M, Kupers R. Brain structural changes in blindness: a systematic review of evidence for cross‑modal plasticity. Neurosci Biobehav Rev. 2023;150:105165. doi:10.1016/j.neubiorev.2023.105165 [doi]
7. Fabri M, Polonara G, Mascioli G, Salvolini U, Manzoni T. Topographical organization of the human corpus callosum: an fMRI mapping study. Brain Res. 2011;1370:99‑111. doi:10.1016/j.brainres.2010.11.039 [doi]
8. Pedersini CA, Fracasso A, Dogar A, Rokers B, Sinha P. Gray matter abnormalities in sight deprivation and sight restoration. Brain Struct Funct. 2025;230:133. doi:10.1007/s00429-025-02994-6 [doi]
9. Ptito M, Schneider FC, Paulson OB, Kupers R. Alterations of the visual pathways in congenital blindness. Exp Brain Res. 2008;187(1):41‑49. doi:10.1007/s00221-008-1273-4 [doi]
10. Ding Z, Newton AT, Xu R, Anderson AW, Morgan VL, Gore JC. Detection of synchronous brain activity in white matter tracts at rest. Proc Natl Acad Sci U S A. 2018;115(3):595‑600. doi:10.1073/pnas.1711567115 [doi]
11. Huang Y, Wei P‑H, Xu L, Chen D, Yang Y, Song W, Yi Y, Jia X, Wu G, Fan Q, et al. Intracranial electrophysiological and structural basis of BOLD functional connectivity in human brain white matter. Nat Commun. 2023;14:3414. doi:10.1038/s41467-023-39067-3 [doi]
12. Wang H, Wang X, Cao X, Huang C, Wang Z, Chen Q, et al. White matter BOLD signals at 7 Tesla reveal visual field maps in optic radiation and vertical occipital fasciculus. Neuroimage. 2023;269:119916. doi:10.1016/j.neuroimage.2023.119916 [doi]
13. Bedny M, Pascual‑Leone A, Dodell‑Feder D, Fedorenko E, Saxe R. Language processing in the occipital cortex of congenitally blind adults. Proc Natl Acad Sci U S A. 2011;108(11):4429‑4434. doi:10.1073/pnas.1014818108 [doi]
14. Mowad O, Miskovic V, Nagarajan S, Kupers R, Ptito M. Compensatory cross‑modal plasticity persists after sight restoration. Front Neurosci. 2020;14:291. doi:10.3389/fnins.2020.00291 [doi]
15. Heine L, Bahri MA, Cavaliere C, Soddu A, Laureys S, Ptito M, Kupers R. Prevalence of increases in functional connectivity in visual, somatosensory and language areas in congenital blindness. Front Neuroanat. 2015;9:86. doi:10.3389/fnana.2015.00086 [doi]
16. Wen Z, Zhou S, Huang P, Dan G, Xie G, Shen D. Altered functional connectivity of primary visual cortex in late blindness. Neuropsychiatr Dis Treat. 2018;14:3317‑3327. doi:10.2147/NDT.S183751 [doi]
17. Yeatman JD, Weiner KS, Pestilli F, Rokem A, Mezer A, Wandell BA. The vertical occipital fasciculus: a century of controversy resolved by in vivo measurements. Proc Natl Acad Sci U S A. 2014;111(48):E5214‑E5223. doi:10.1073/pnas.1418503111 [doi]
18. Ding Z, Yao Y, Zhao T, Newton AT, Xu R, Swearingen B, Gore JC. Cortical modulation of resting‑state BOLD signals in human white matter. Sci Rep. 2025;15:30056. doi:10.1038/s41598-025-14352-x [doi]
19. Röder B, Kekunnaya R, Guerreiro MJS. Neural mechanisms of visual sensitive periods in humans. Neurosci Biobehav Rev. 2021;120:86‑99. doi:10.1016/j.neubiorev.2020.10.030 [doi]
20. Knudsen EI, Zheng W, DeBello WM. Traces of learning in the auditory localization pathway. Proc Natl Acad Sci U S A. 2000;97:11815‑11820. doi:10.1073/pnas.97.22.11815 [doi]
21. Kral A, Dorman MF, Wilson BS. Neuronal development of hearing and language: cochlear implants and critical periods. Annu Rev Neurosci. 2019;42:47‑65. doi:10.1146/annurev-neuro-080317-061513 [doi]
22. Knudsen EI. Sensitive periods in the development of the brain and behavior. J Cogn Neurosci. 2004;16(8):1412‑1425. doi:10.1162/0898929042304796 [doi]

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