531-02-013 / 531-02-013 ISMRM Abstract

Patterns of Deep Brain Stimulation Target Engagement Correlate with Postoperative Cognitive Change in Parkinson’s Disease

Primary: Neuro - Neuromodulation

Secondary: Neuro - Parkinson's Disease

531-02-013 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace

Keywords: Biomarkers Deep Brain Stimulation Cognitive Function Therapeutic response Stimulation Volumes

Accepted

Devin Schoen ^1,2, Meenakshi Singhal¹, Skyler Deutsch¹, Deborah Cahn³, Caroline A Racine³, Sarah S Wang⁴, Ian O Bledsoe⁴, Jill L Ostrem⁴, Philip A Starr^2,3, Doris D Wang^2,3, Melanie A Morrison^1,2

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, United States of America

²Graduate Group in Bioengineering, University of California, Berkeley, United States of America

³Department of Neurological Surgery, University of California San Francisco, San Francisco, United States of America

⁴Department of Neurology, University of California San Francisco, San Francisco, United States of America

Presenting Author: Devin Schoen

Synopsis

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References

1. Akram, H., Sotiropoulos, S. N., Jbabdi, S., Georgiev, D., Mahlknecht, P., Hyam, J., Foltynie, T., Limousin, P., De Vita, E., Jahanshahi, M., Hariz, M., Ashburner, J., Behrens, T., & Zrinzo, L. (2017). Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson’s disease. NeuroImage, 158, 332–345. https://doi.org/10.1016/j.neuroimage.2017.07.012 [doi]

2. Dembek, T. A., Roediger, J., Horn, A., Reker, P., Oehrn, C., Dafsari, H. S., Li, N., Kühn, A. A., Fink, G. R., Visser‐Vandewalle, V., Barbe, M. T., & Timmermann, L. (2019). Probabilistic sweet spots predict motor outcome for deep brain stimulation in Parkinson disease. Annals of Neurology, 86(4), 527–538. https://doi.org/10.1002/ana.25567 [doi]

3. Drapier, D., Drapier, S., Sauleau, P., Haegelen, C., Raoul, S., Biseul, I., Peron, J., Lallement, F., Rivier, I., Reymann, J. M., Edan, G., Verin, M., & Millet, B. (2006). Does subthalamic nucleus stimulation induce apathy in Parkinson’s disease? Journal of Neurology, 253(8), 1083–1091. https://doi.org/10.1007/s00415-006-0177-0 [doi]

4. Ewert, S., Plettig, P., Li, N., Chakravarty, M. M., Collins, D. L., Herrington, T. M., Kühn, A. A., & Horn, A. (2018). Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural connectivity. NeuroImage, 170, 271–282. https://doi.org/10.1016/j.neuroimage.2017.05.015 [doi]

5. Le Jeune, F., Péron, J., Grandjean, D., Drapier, S., Haegelen, C., Garin, E., Millet, B., & Vérin, M. (2010). Subthalamic nucleus stimulation affects limbic and associative circuits: A PET study. European Journal of Nuclear Medicine and Molecular Imaging, 37(8), 1512–1520. https://doi.org/10.1007/s00259-010-1436-y [doi]

6. Maassen, G. H., Bossema, E., & Brand, N. (2009). Reliable change and practice effects: Outcomes of various indices compared. Journal of Clinical and Experimental Neuropsychology, 31(3), 339–352. https://doi.org/10.1080/13803390802169059 [doi]

7. Middleton, F. (2000). Basal ganglia and cerebellar loops: Motor and cognitive circuits. Brain Research Reviews, 31(2–3), 236–250. https://doi.org/10.1016/S0165-0173(99)00040-5 [doi]

8. Neudorfer, C., Butenko, K., Oxenford, S., Rajamani, N., Achtzehn, J., Goede, L., Hollunder, B., Ríos, A. S., Hart, L., Tasserie, J., Fernando, K. B., Nguyen, T. A. K., Al-Fatly, B., Vissani, M., Fox, M., Richardson, R. M., Van Rienen, U., Kühn, A. A., Husch, A. D., … Horn, A. (2023). Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks. NeuroImage, 268, 119862. https://doi.org/10.1016/j.neuroimage.2023.119862 [doi]

9. Tanner, C. M., & Ostrem, J. L. (2024). Parkinson’s Disease. New England Journal of Medicine, 391(5), 442–452. https://doi.org/10.1056/NEJMra2401857 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/531-02-013