Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
466-03-006 Registered Abstract

Myelin Water Fraction map generated from 3D Quantitative Transient-state Imaging using a multi-compartment dictionary

Primary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI
Secondary: Neuro - White Matter
466-03-006 · Pulse Sequences with a Focus on Quantitative Imaging · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row G
Keywords: Myelin water fraction 3D GRASE 3D QTI
Accepted
Ilaria Neri 1,2,3, Noemi Sgambelluri3, Laura Nunez-Gonzalez4, Dirk H. J. Poot3, Matteo Cencini5, Marta Lancione5, Laura Biagi5, Michela Tosetti5, Maria Picchio2,6, Arturo Chiti2,6, Cristina Baldoli1, Juan A Hernandez-Tamames3,7, Paola Scifo2
1Neuroradiology Department, IRCCS San Raffaele Scientific Institute, Milan, Italy
2Nuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy
3Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands
4GE HealthCare, Madrid, Spain
5IRCCS Stella Maris Foundation, Pisa, Italy
6Vita-Salute San Raffaele University, Milan, Italy
7Imaging Physics, TU Delft, Delft, Netherlands
Presenting Author: Ilaria Neri

Synopsis

Motivation:
Goals:
Approach:
Hypothesis:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. van der Weijden, Chris WJ, et al. "Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status." Brain 146.4 (2023): 1243-1266. https://doi.org/10.1093/brain/awac436 [doi]
2. Prasloski, Thomas, et al. "Rapid whole cerebrum myelin water imaging using a 3D GRASE sequence." Neuroimage 63.1 (2012): 533-539. https://doi.org/10.1016/j.neuroimage.2012.06.064 [doi]
3. Uddin, Md Nasir, et al. "Comparisons between multi-component myelin water fraction, T1w/T2w ratio, and diffusion tensor imaging measures in healthy human brain structures." Scientific reports 9.1 (2019): 2500. https://doi.org/10.1038/s41598-019-39199-x [doi]
4. Ma, Dan, et al. "Magnetic resonance fingerprinting." Nature 495.7440 (2013): 187-192. https://doi.org/10.1038/nature11971 [doi]
5. Gómez, Pedro A., et al. "Rapid three-dimensional multiparametric MRI with quantitative transient-state imaging." Scientific reports 10.1 (2020): 13769. https://doi.org/10.1038/s41598-020-70789-2 [doi]
6. Lancione, Marta, et al. "Repeatability and reproducibility of joint T1-T2 transient-state relaxometry across multiple vendors and implementations at 3T in phantom and human brain." NeuroImage (2025): 121471. https://doi.org/10.1016/j.neuroimage.2025.121471 [doi]
7. https://mriresearch.med.ubc.ca/news-projects/myelin-water-fraction/
8. Cencini, Matteo, et al. "Myelin water fraction mapping in developing children using magnetic resonance fingerprinting." Proc Intl Soc Mag Reson Med. Vol. 29, p. 0165. 2021.
9. Chen, Yong, et al. "MR fingerprinting enables quantitative measures of brain tissue relaxation times and myelin water fraction in the first five years of life." Neuroimage 186 (2019): 782-793. https://doi.org/10.1016/j.neuroimage.2018.11.038 [doi]
10. Wyatt, Cory R., and Alexander R. Guimaraes. "3D MR fingerprinting using Seiffert spirals." Magnetic Resonance in Medicine 88.1 (2022): 151-163. https://doi.org/10.1002/mrm.29197 [doi]
11. Faizy, Tobias D., et al. "Age-related measurements of the myelin water fraction derived from 3D multi-echo GRASE reflect myelin content of the cerebral white matter." Scientific reports 8.1 (2018): 14991. https://doi.org/10.1038/s41598-018-33112-8 [doi]
12. Lancione, Marta, et al. "Magnetic resonance fingerprinting‐based myelin water fraction mapping for the assessment of white matter maturation and integrity in typical development and leukodystrophies." NMR in Biomedicine 37.6 (2024): e5114. https://doi.org/10.1002/nbm.5114 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/466-03-006