Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
405-02-005 ISMRM Abstract

Performance of Myelin Water Imaging in vivo: Imaging-Histopathologic Correlation in Toxin-Induced Demyelination

Primary: Preclinical Animal & in vitro MR - Biomarkers
Secondary: Neuro - Multiple Sclerosis
405-02-005 · What's New in Multiple Sclerosis? · Tuesday, 12 May, 8:20 AM–10:10 AM · Ballroom West
Keywords: Multiple Sclerosis Biomarker validation Myelin water imaging Remyelination
Accepted
Leah Zuroff1,2, Erin C Argentieri3, Aryil L Bechtel1,2, Christian Cordano2,4, David Stefanoff2,4, Caroline Guglielmetti5, Roland G Henry2,4,6, Peder Larson6, Ari J Green2,4,7
1Department of Neurology, University of California San Francisco, San Francisco, United States of America
2Department of Neurology, Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, California, United States of America
3University of California San Francisco — Radiology and biomedical imaging, San Francisco, United States of America
4Department of Neurology, University Of California, San Francisco (UCSF), United States of America
5Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, United States of America
6Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America
7Department of Ophthalmology, University Of California, San Francisco (UCSF), United States of America
Presenting Author: Donghyun Hong

Synopsis

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References

1. Caverzasi E, Papinutto N, Cordano C, Kirkish G, Gundel TJ, Zhu A, Akula AV, Boscardin WJ, Neeb H, Henry RG, Chan JR, Green AJ. MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2217635120. doi: 10.1073/pnas.2217635120. Epub 2023 May 8. PMID: 37155847; PMCID: PMC10193980. [doi] [pmid]
2. Laule C, Moore GRW. Myelin water imaging to detect demyelination and remyelination and its validation in pathology. Brain Pathol. 2018 Sep;28(5):750-764. doi: 10.1111/bpa.12645. PMID: 30375119; PMCID: PMC8028667. [doi] [pmid]
3. Matsushima GK, Morell P. The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol. 2001 Jan;11(1):107-16. doi: 10.1111/j.1750-3639.2001.tb00385.x. PMID: 11145196; PMCID: PMC8098267. [doi] [pmid]
4. Doucette J, Kames C, Rauscher A. DECAES - DEcomposition and Component Analysis of Exponential Signals. Z Med Phys. 2020 Nov;30(4):271-278. doi: 10.1016/j.zemedi.2020.04.001. Epub 2020 May 22. PMID: 32451148. [doi] [pmid]
5. Doucette J, Kames C, Rauscher A. DECAES - DEcomposition and Component Analysis of Exponential Signals. Z Med Phys. 2020 Nov;30(4):271-278. doi: 10.1016/j.zemedi.2020.04.001. Epub 2020 May 22. PMID: 32451148. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/405-02-005