Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
367-02-001 ISMRM Abstract

Band-selective IR PRESS for brain tumor spectroscopy allows robust detection of lactate

Primary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
Secondary: Preclinical Animal & in vitro MR - Biomarkers
367-02-001 · Cancer Detection and Therapies · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row H
Keywords: Preclinical MRS Lactate In vivo proton magnetic resonance spectroscopy
Accepted
Shun Kishimoto 1,2, Daniel R Crooks2, Peng Lu3, Yuki Shibata2, Olga Kim3, Jeeva Munasinghe4,5,6, Otowa Yasunori1, Yamashita Kota1, Kazutoshi Yamamoto1, Jing Wu3, Murali Krishna5,7, jeff brender1
1Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States of America
2Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States of America
3Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States of America
4NINDS, Bethesda, United States of America
5National Institutes of Health (NIH), Bethesda, United States of America
6Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States of America
7Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States of America
Presenting Author: Shun Kishimoto

Synopsis

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References

1. Star-Lack J, Spielman D, Adalsteinsson E, Kurhanewicz J, Terris DJ, Vigneron DB. In vivo lactate editing with simultaneous detection of choline, creatine, NAA, and lipid singlets at 1.5 T using PRESS excitation with applications to the study of brain and head and neck tumors. J Magn Reson. 1998;133(2):243-254.
2. Harris AD, Saleh MG, Edden RA. Edited (1) H magnetic resonance spectroscopy in vivo: Methods and metabolites. Magn Reson Med. 2017;77(4):1377-1389.
3. Choi IY, Andronesi OC, Barker P, et al. Spectral editing in (1) H magnetic resonance spectroscopy: Experts' consensus recommendations. NMR Biomed. 2021;34(5):e4411.
4. Payne GS, Harris LM, Cairns GS, et al. Validating a robust double-quantum-filtered (1) H MRS lactate measurement method in high-grade brain tumours. NMR Biomed. 2016;29(10):1420-1426.
5. Balchandani P, Spielman D. Fat suppression for 1H MRSI at 7T using spectrally selective adiabatic inversion recovery. Magn Reson Med. 2008;59(5):980-988.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/367-02-001